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- NCIT_C91806 NCIT_NHC0 "C91806" @default.
- NCIT_C91806 NCIT_P106 "Functional Concept" @default.
- NCIT_C91806 NCIT_P108 "Shigellosis Pathway" @default.
- NCIT_C91806 NCIT_P207 "C2984571" @default.
- NCIT_C91806 NCIT_P215 "hsa05131" @default.
- NCIT_C91806 NCIT_P325 "Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestinal epithelium by exploiting epithelial-cell functions and circumventing the host innate immune response. During basolateral entry into the host-cell cytoplasm, Shigella deliver a subset of effectors into the host cells through the type III secretion system. The effectors induce membrane ruffling through the stimulation of the Rac1-WAVE-Arp2/3 pathway, enabling bacterial entry into the epithelial cells. During multiplication within the cells, Shigella secrete another subset of effectors. VirG induces actin polymerization at one pole of the bacteria, allowing the bacteria to spread intracellularly and to infect adjacent cells. OspF, OspG and IpaH(9.8) downregulate the production of proinflammatory cytokines such as IL-8, helping bacteria circumvent the innate immune response." @default.
- NCIT_C91806 normalizedInformationContent "69.936281813332869" @default.
- NCIT_C91806 referenceCount "94" @default.
- NCIT_C91806 hasExactSynonym "Shigella Infection Pathway" @default.
- NCIT_C91806 hasExactSynonym "Shigellosis Pathway" @default.
- NCIT_C91806 hasExactSynonym "Shigellosis" @default.
- NCIT_C91806 type Class @default.
- NCIT_C91806 isDefinedBy ncit.owl @default.
- NCIT_C91806 label "Shigellosis Pathway" @default.
- NCIT_C91806 subClassOf NCIT_C20633 @default.
- NCIT_C91806 subClassOf NCIT_C39701 @default.
- NCIT_C91806 subClassOf NCIT_C39738 @default.
- NCIT_C91806 subClassOf NCIT_C91806 @default.