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- NCIT_C92574 IAO_0000115 "A small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity. Apalutamide binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells." @default.
- NCIT_C92574 NCIT_A32 NCIT_C1909 @default.
- NCIT_C92574 NCIT_A7 NCIT_C17063 @default.
- NCIT_C92574 NCIT_NHC0 "C92574" @default.
- NCIT_C92574 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C92574 NCIT_P107 "Apalutamide" @default.
- NCIT_C92574 NCIT_P108 "Apalutamide" @default.
- NCIT_C92574 NCIT_P207 "C2985183" @default.
- NCIT_C92574 NCIT_P210 "956104-40-8" @default.
- NCIT_C92574 NCIT_P302 "non-metastatic castration-resistant prostate cancer" @default.
- NCIT_C92574 NCIT_P319 "4T36H88UA7" @default.
- NCIT_C92574 NCIT_P322 "CTRP" @default.
- NCIT_C92574 NCIT_P322 "FDA" @default.
- NCIT_C92574 NCIT_P322 "GDC" @default.
- NCIT_C92574 NCIT_P322 "OORO" @default.
- NCIT_C92574 NCIT_P329 "683082" @default.
- NCIT_C92574 NCIT_P330 "683082" @default.
- NCIT_C92574 NCIT_P375 "Apalutamide" @default.
- NCIT_C92574 NCIT_P399 "683082" @default.
- NCIT_C92574 normalizedInformationContent "88.143637090998837" @default.
- NCIT_C92574 referenceCount "6" @default.
- NCIT_C92574 hasExactSynonym "4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro(3.4)octan-5-yl)-2-fluoro-N-methylbenzamide" @default.
- NCIT_C92574 hasExactSynonym "APALUTAMIDE" @default.
- NCIT_C92574 hasExactSynonym "ARN 509" @default.
- NCIT_C92574 hasExactSynonym "ARN-509" @default.
- NCIT_C92574 hasExactSynonym "ARN509" @default.
- NCIT_C92574 hasExactSynonym "Apalutamide" @default.
- NCIT_C92574 hasExactSynonym "Erleada" @default.
- NCIT_C92574 hasExactSynonym "JNJ 56021927" @default.
- NCIT_C92574 hasExactSynonym "JNJ-56021927" @default.
- NCIT_C92574 hasExactSynonym "apalutamide" @default.
- NCIT_C92574 inSubset NCIT_C116977 @default.
- NCIT_C92574 inSubset NCIT_C116978 @default.
- NCIT_C92574 inSubset NCIT_C128784 @default.
- NCIT_C92574 inSubset NCIT_C157711 @default.
- NCIT_C92574 inSubset NCIT_C157712 @default.
- NCIT_C92574 inSubset NCIT_C176424 @default.
- NCIT_C92574 inSubset NCIT_C177537 @default.
- NCIT_C92574 inSubset NCIT_C192234 @default.
- NCIT_C92574 inSubset NCIT_C63923 @default.
- NCIT_C92574 type Class @default.
- NCIT_C92574 isDefinedBy ncit.owl @default.
- NCIT_C92574 label "Apalutamide" @default.
- NCIT_C92574 subClassOf NCIT_C146993 @default.
- NCIT_C92574 subClassOf NCIT_C147908 @default.
- NCIT_C92574 subClassOf NCIT_C163758 @default.
- NCIT_C92574 subClassOf NCIT_C1908 @default.
- NCIT_C92574 subClassOf NCIT_C1909 @default.
- NCIT_C92574 subClassOf NCIT_C242 @default.
- NCIT_C92574 subClassOf NCIT_C274 @default.
- NCIT_C92574 subClassOf NCIT_C547 @default.
- NCIT_C92574 subClassOf NCIT_C92574 @default.