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- NCIT_C92576 IAO_0000115 "A deoxycytidine analog and high-affinity substrate for deoxycytidine kinase (DCK), labeled with fluorine F 18, with potential diagnostic activity upon positron emission tomography (PET) imaging. [18F]L-FAC is preferentially taken up by and accumulated in cells with high deoxycytidine kinase (DCK) levels, such as in tumor cells with dysregulated nucleoside metabolism. Upon uptake through the nucleoside transporter, [18F]L-FAC is phosphorylated by DCK and, subsequently, the 18F moiety can be visualized upon PET imaging. As many nucleoside analog prodrugs are chemotherapeutic agents that require DCK for activation, [18F]L-FAC can potentially be used as a marker to predict chemotherapeutic efficacy of these prodrugs. In addition, as DCK is upregulated in certain immune cells, such as activated T-cells, [18F]L-FAC can also be used to measure immune activation in response to immunomodulating agents. DCK, a rate-limiting enzyme in the nucleoside salvage pathway for DNA synthesis, is overexpressed in certain solid tumors, lymphoid and myeloid malignancies and certain immune cells, such as proliferating T-lymphocytes." @default.
- NCIT_C92576 NCIT_A7 NCIT_C16498 @default.
- NCIT_C92576 NCIT_NHC0 "C92576" @default.
- NCIT_C92576 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C92576 NCIT_P107 "[18F]L-FAC" @default.
- NCIT_C92576 NCIT_P108 "[18F]L-FAC" @default.
- NCIT_C92576 NCIT_P207 "C2985185" @default.
- NCIT_C92576 NCIT_P322 "CTRP" @default.
- NCIT_C92576 NCIT_P329 "683739" @default.
- NCIT_C92576 NCIT_P330 "683739" @default.
- NCIT_C92576 NCIT_P399 "683739" @default.
- NCIT_C92576 normalizedInformationContent "100" @default.
- NCIT_C92576 referenceCount "1" @default.
- NCIT_C92576 hasExactSynonym "1-(2-Deoxy-2-[18F]fluoroarabinofuranosyl) Cytosine" @default.
- NCIT_C92576 hasExactSynonym "18F-FAC" @default.
- NCIT_C92576 hasExactSynonym "L-18F-FAC" @default.
- NCIT_C92576 hasExactSynonym "[18F]L-FAC" @default.
- NCIT_C92576 inSubset NCIT_C116977 @default.
- NCIT_C92576 inSubset NCIT_C116978 @default.
- NCIT_C92576 inSubset NCIT_C176424 @default.
- NCIT_C92576 type Class @default.
- NCIT_C92576 isDefinedBy ncit.owl @default.
- NCIT_C92576 label "[18F]L-FAC" @default.
- NCIT_C92576 subClassOf NCIT_C1446 @default.
- NCIT_C92576 subClassOf NCIT_C1908 @default.
- NCIT_C92576 subClassOf NCIT_C1909 @default.
- NCIT_C92576 subClassOf NCIT_C2124 @default.
- NCIT_C92576 subClassOf NCIT_C92576 @default.