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- NCIT_C94207 IAO_0000115 "A synthetic oligonucleotide based on a proprietary double stem-loop immunomodulator design with potential immunostimulating activity. Lefitolimod binds to and activates intracellular Toll-like receptor 9 (TLR9) in monocytes/macrophages, plasmacytoidal and myeloid dendritic cells (DCs), and natural killer (NK) cells, initiating immune signaling pathways and inducing T-helper 1 cell (Th1) production leading to the production of memory T cells and a Th1-mediated immune response. By activating the immune system, MGN1703 may attack tumor associated antigen (TAAs). TLR9 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity." @default.
- NCIT_C94207 NCIT_A32 NCIT_C1909 @default.
- NCIT_C94207 NCIT_A7 NCIT_C96048 @default.
- NCIT_C94207 NCIT_NHC0 "C94207" @default.
- NCIT_C94207 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C94207 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C94207 NCIT_P107 "Lefitolimod" @default.
- NCIT_C94207 NCIT_P108 "Lefitolimod" @default.
- NCIT_C94207 NCIT_P207 "C2986392" @default.
- NCIT_C94207 NCIT_P210 "1548439-51-5" @default.
- NCIT_C94207 NCIT_P319 "6SO72A12FN" @default.
- NCIT_C94207 NCIT_P322 "CTRP" @default.
- NCIT_C94207 NCIT_P322 "FDA" @default.
- NCIT_C94207 NCIT_P322 "GDC" @default.
- NCIT_C94207 NCIT_P329 "686500" @default.
- NCIT_C94207 NCIT_P330 "686500" @default.
- NCIT_C94207 NCIT_P375 "Lefitolimod" @default.
- NCIT_C94207 NCIT_P399 "686500" @default.
- NCIT_C94207 normalizedInformationContent "100" @default.
- NCIT_C94207 referenceCount "1" @default.
- NCIT_C94207 hasExactSynonym "LEFITOLIMOD" @default.
- NCIT_C94207 hasExactSynonym "Lefitolimod" @default.
- NCIT_C94207 hasExactSynonym "MGN-1703" @default.
- NCIT_C94207 hasExactSynonym "MGN1703" @default.
- NCIT_C94207 hasExactSynonym "dSLIM-30L1" @default.
- NCIT_C94207 inSubset NCIT_C116977 @default.
- NCIT_C94207 inSubset NCIT_C116978 @default.
- NCIT_C94207 inSubset NCIT_C128784 @default.
- NCIT_C94207 inSubset NCIT_C157711 @default.
- NCIT_C94207 inSubset NCIT_C157712 @default.
- NCIT_C94207 inSubset NCIT_C176424 @default.
- NCIT_C94207 inSubset NCIT_C177537 @default.
- NCIT_C94207 inSubset NCIT_C63923 @default.
- NCIT_C94207 type Class @default.
- NCIT_C94207 isDefinedBy ncit.owl @default.
- NCIT_C94207 label "Lefitolimod" @default.
- NCIT_C94207 subClassOf NCIT_C1908 @default.
- NCIT_C94207 subClassOf NCIT_C1909 @default.
- NCIT_C94207 subClassOf NCIT_C2139 @default.
- NCIT_C94207 subClassOf NCIT_C308 @default.
- NCIT_C94207 subClassOf NCIT_C94207 @default.