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- NCIT_C94218 IAO_0000115 "An autologous dendritic cell (DC) cancer vaccine with potential immunostimulatory activity. Anti-CTLA4 MoAb RNA/GITRL RNA-transfected DC vaccine is prepared by transfecting DCs with RNAs encoding humanized heavy and light chains of the anti-CTLA4 (cytotoxic T-Lymphocyte-Associated Antigen 4) monoclonal antibody and tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18 or GlTRL); expression of anti-CTLA4 blocks the inhibitory effect of CTLA4 on the activation of T-lymphocytes, while expression of GlTRL modulates T lymphocyte survival in peripheral tissues. Co-vaccination of this vaccine with melanoma antigen specific vaccine may eliminate the adverse effects associated with systemic administration of immune modulators, while also enhancing vaccine-induced immune responses." @default.
- NCIT_C94218 NCIT_A7 NCIT_C17489 @default.
- NCIT_C94218 NCIT_NHC0 "C94218" @default.
- NCIT_C94218 NCIT_P106 "Cell" @default.
- NCIT_C94218 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C94218 NCIT_P107 "Anti-CTLA4 MoAb RNA/GITRL RNA-transfected Autologous Dendritic Cell Vaccine" @default.
- NCIT_C94218 NCIT_P108 "Anti-CTLA4 MoAb RNA/GITRL RNA-transfected Autologous Dendritic Cell Vaccine" @default.
- NCIT_C94218 NCIT_P208 "CL426031" @default.
- NCIT_C94218 NCIT_P322 "CTRP" @default.
- NCIT_C94218 NCIT_P329 "687567" @default.
- NCIT_C94218 NCIT_P330 "687567" @default.
- NCIT_C94218 NCIT_P399 "687567" @default.
- NCIT_C94218 normalizedInformationContent "100" @default.
- NCIT_C94218 referenceCount "1" @default.
- NCIT_C94218 hasExactSynonym "Anti-CTLA4 MoAb RNA/GITRL RNA-transfected Autologous Dendritic Cell Vaccine" @default.
- NCIT_C94218 hasExactSynonym "GITRL/antiCTLA4 RNA DC" @default.
- NCIT_C94218 hasExactSynonym "anti-CTLA-4 mAb Heavy and Light Chain RNA/GITRL RNA-transfected Autologous DC" @default.
- NCIT_C94218 inSubset NCIT_C116977 @default.
- NCIT_C94218 inSubset NCIT_C116978 @default.
- NCIT_C94218 inSubset NCIT_C128784 @default.
- NCIT_C94218 inSubset NCIT_C176424 @default.
- NCIT_C94218 type Class @default.
- NCIT_C94218 isDefinedBy ncit.owl @default.
- NCIT_C94218 label "Anti-CTLA4 MoAb RNA/GITRL RNA-transfected Autologous Dendritic Cell Vaccine" @default.
- NCIT_C94218 subClassOf NCIT_C129820 @default.
- NCIT_C94218 subClassOf NCIT_C1663 @default.
- NCIT_C94218 subClassOf NCIT_C172787 @default.
- NCIT_C94218 subClassOf NCIT_C181141 @default.
- NCIT_C94218 subClassOf NCIT_C1908 @default.
- NCIT_C94218 subClassOf NCIT_C1909 @default.
- NCIT_C94218 subClassOf NCIT_C274 @default.
- NCIT_C94218 subClassOf NCIT_C28308 @default.
- NCIT_C94218 subClassOf NCIT_C28310 @default.
- NCIT_C94218 subClassOf NCIT_C307 @default.
- NCIT_C94218 subClassOf NCIT_C308 @default.
- NCIT_C94218 subClassOf NCIT_C923 @default.
- NCIT_C94218 subClassOf NCIT_C94218 @default.