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- NCIT_C94219 IAO_0000115 "A tetravalent bispecific antibody directed against human CD30 and the human low affinity IgG Fc region receptor (FCGR3A; CD16A), with potential immunomodulating and antineoplastic activities. Upon administration, acimtamig binds to the CD16A expressed on natural killer (NK) cells with two of its binding sites and to CD30 on CD30-expressing tumor cells with the other two binding sites, thereby selectively cross-linking tumor and NK cells. This may result in NK cell activation, antibody-dependent cellular cytotoxicity (ADCC) and eventually tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is overexpressed in hematologic malignancies; CD16A is specifically expressed on the surface of NK cells." @default.
- NCIT_C94219 NCIT_A32 NCIT_C1909 @default.
- NCIT_C94219 NCIT_A7 NCIT_C38559 @default.
- NCIT_C94219 NCIT_A7 NCIT_C38906 @default.
- NCIT_C94219 NCIT_NHC0 "C94219" @default.
- NCIT_C94219 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C94219 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C94219 NCIT_P107 "Acimtamig" @default.
- NCIT_C94219 NCIT_P108 "Acimtamig" @default.
- NCIT_C94219 NCIT_P208 "CL426032" @default.
- NCIT_C94219 NCIT_P210 "2738880-26-5" @default.
- NCIT_C94219 NCIT_P319 "ND470TT8Y3" @default.
- NCIT_C94219 NCIT_P322 "CTRP" @default.
- NCIT_C94219 NCIT_P322 "FDA" @default.
- NCIT_C94219 NCIT_P322 "GDC" @default.
- NCIT_C94219 NCIT_P329 "687622" @default.
- NCIT_C94219 NCIT_P330 "687622" @default.
- NCIT_C94219 NCIT_P375 "Anti-CD30/CD16A Monoclonal Antibody AFM13" @default.
- NCIT_C94219 NCIT_P399 "687622" @default.
- NCIT_C94219 NCIT_R124 NCIT_C17710 @default.
- NCIT_C94219 NCIT_R124 NCIT_C17828 @default.
- NCIT_C94219 NCIT_R124 NCIT_C18219 @default.
- NCIT_C94219 NCIT_R124 NCIT_C19986 @default.
- NCIT_C94219 NCIT_R124 NCIT_C40474 @default.
- NCIT_C94219 normalizedInformationContent "100" @default.
- NCIT_C94219 referenceCount "1" @default.
- NCIT_C94219 hasExactSynonym "ACIMTAMIG" @default.
- NCIT_C94219 hasExactSynonym "AFM13" @default.
- NCIT_C94219 hasExactSynonym "Acimtamig" @default.
- NCIT_C94219 hasExactSynonym "Anti-CD30/CD16A Monoclonal Antibody AFM13" @default.
- NCIT_C94219 inSubset NCIT_C116977 @default.
- NCIT_C94219 inSubset NCIT_C116978 @default.
- NCIT_C94219 inSubset NCIT_C128784 @default.
- NCIT_C94219 inSubset NCIT_C157711 @default.
- NCIT_C94219 inSubset NCIT_C157712 @default.
- NCIT_C94219 inSubset NCIT_C176424 @default.
- NCIT_C94219 inSubset NCIT_C177537 @default.
- NCIT_C94219 inSubset NCIT_C63923 @default.
- NCIT_C94219 type Class @default.
- NCIT_C94219 isDefinedBy ncit.owl @default.
- NCIT_C94219 label "Acimtamig" @default.
- NCIT_C94219 subClassOf NCIT_C129821 @default.
- NCIT_C94219 subClassOf NCIT_C129822 @default.
- NCIT_C94219 subClassOf NCIT_C163758 @default.
- NCIT_C94219 subClassOf NCIT_C164002 @default.
- NCIT_C94219 subClassOf NCIT_C164005 @default.
- NCIT_C94219 subClassOf NCIT_C1908 @default.
- NCIT_C94219 subClassOf NCIT_C1909 @default.
- NCIT_C94219 subClassOf NCIT_C20401 @default.
- NCIT_C94219 subClassOf NCIT_C274 @default.
- NCIT_C94219 subClassOf NCIT_C307 @default.
- NCIT_C94219 subClassOf NCIT_C308 @default.
- NCIT_C94219 subClassOf NCIT_C94219 @default.