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- NCIT_C94224 IAO_0000115 "An orally bioavailable, highly soluble phosphate prodrug of B-raf (BRAF) protein kinase with potential antineoplastic activity. BRAF inhibitor ARQ 736 is converted into its active form ARQ 680 in the presence of phosphatases. In turn, ARQ 680 selectively binds to and inhibits the activity of oncogenic B-raf, which may inhibit the proliferation of tumor cells expressing mutated B-raf gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. The valine to glutamic acid substitution at residue 600 (V600E) accounts for about 90% of BRAF gene mutations." @default.
- NCIT_C94224 NCIT_A32 NCIT_C1909 @default.
- NCIT_C94224 NCIT_A7 NCIT_C17476 @default.
- NCIT_C94224 NCIT_NHC0 "C94224" @default.
- NCIT_C94224 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C94224 NCIT_P107 "BRAF Inhibitor ARQ 736" @default.
- NCIT_C94224 NCIT_P108 "BRAF Inhibitor ARQ 736" @default.
- NCIT_C94224 NCIT_P208 "CL433988" @default.
- NCIT_C94224 NCIT_P210 "1228237-57-7" @default.
- NCIT_C94224 NCIT_P319 "Y2H4S74Y8U" @default.
- NCIT_C94224 NCIT_P322 "CTRP" @default.
- NCIT_C94224 NCIT_P322 "FDA" @default.
- NCIT_C94224 NCIT_P322 "GDC" @default.
- NCIT_C94224 NCIT_P329 "688029" @default.
- NCIT_C94224 NCIT_P330 "688029" @default.
- NCIT_C94224 NCIT_P375 "BRAF Inhibitor ARQ 736" @default.
- NCIT_C94224 NCIT_P399 "688029" @default.
- NCIT_C94224 normalizedInformationContent "100" @default.
- NCIT_C94224 referenceCount "1" @default.
- NCIT_C94224 hasExactSynonym "AQ 736" @default.
- NCIT_C94224 hasExactSynonym "ARQ-736" @default.
- NCIT_C94224 hasExactSynonym "BRAF Inhibitor ARQ 736" @default.
- NCIT_C94224 inSubset NCIT_C116977 @default.
- NCIT_C94224 inSubset NCIT_C116978 @default.
- NCIT_C94224 inSubset NCIT_C128784 @default.
- NCIT_C94224 inSubset NCIT_C157711 @default.
- NCIT_C94224 inSubset NCIT_C157712 @default.
- NCIT_C94224 inSubset NCIT_C176424 @default.
- NCIT_C94224 inSubset NCIT_C177537 @default.
- NCIT_C94224 inSubset NCIT_C63923 @default.
- NCIT_C94224 type Class @default.
- NCIT_C94224 isDefinedBy ncit.owl @default.
- NCIT_C94224 label "BRAF Inhibitor ARQ 736" @default.
- NCIT_C94224 subClassOf NCIT_C129824 @default.
- NCIT_C94224 subClassOf NCIT_C129825 @default.
- NCIT_C94224 subClassOf NCIT_C1404 @default.
- NCIT_C94224 subClassOf NCIT_C155322 @default.
- NCIT_C94224 subClassOf NCIT_C163758 @default.
- NCIT_C94224 subClassOf NCIT_C1908 @default.
- NCIT_C94224 subClassOf NCIT_C1909 @default.
- NCIT_C94224 subClassOf NCIT_C2189 @default.
- NCIT_C94224 subClassOf NCIT_C2336 @default.
- NCIT_C94224 subClassOf NCIT_C274 @default.
- NCIT_C94224 subClassOf NCIT_C471 @default.
- NCIT_C94224 subClassOf NCIT_C61074 @default.
- NCIT_C94224 subClassOf NCIT_C94224 @default.