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- NCIT_C95023 IAO_0000115 "A humanized, Fc disabled anti-human glucocorticoid-induced tumor necrosis factor receptor (GITR) monoclonal antibody (MoAb) with immunomodulating activity. Anti-human GITR MoAb TRX518 blocks the interaction of GITR, found on multiple types of T cells, with its ligand, thereby inducing both the activation of tumor-antigen-specific T effector cells, as well as abrogating the suppression induced by inappropriately activated T regulatory cells. This agent is shown to act synergistically with chemotherapeutic drugs in multiple cancer models." @default.
- NCIT_C95023 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95023 NCIT_A7 NCIT_C105568 @default.
- NCIT_C95023 NCIT_NHC0 "C95023" @default.
- NCIT_C95023 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C95023 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95023 NCIT_P107 "Anti-human GITR Monoclonal Antibody TRX518" @default.
- NCIT_C95023 NCIT_P108 "Anti-human GITR Monoclonal Antibody TRX518" @default.
- NCIT_C95023 NCIT_P208 "CL426557" @default.
- NCIT_C95023 NCIT_P322 "CTRP" @default.
- NCIT_C95023 NCIT_P322 "GDC" @default.
- NCIT_C95023 NCIT_P329 "689549" @default.
- NCIT_C95023 NCIT_P330 "689549" @default.
- NCIT_C95023 NCIT_P375 "Anti-human GITR Monoclonal Antibody TRX518" @default.
- NCIT_C95023 NCIT_P399 "689549" @default.
- NCIT_C95023 NCIT_R124 NCIT_C17710 @default.
- NCIT_C95023 NCIT_R124 NCIT_C17828 @default.
- NCIT_C95023 NCIT_R124 NCIT_C18219 @default.
- NCIT_C95023 NCIT_R124 NCIT_C19986 @default.
- NCIT_C95023 NCIT_R124 NCIT_C40474 @default.
- NCIT_C95023 normalizedInformationContent "100" @default.
- NCIT_C95023 referenceCount "1" @default.
- NCIT_C95023 hasExactSynonym "Anti-huGITR MoAb TRX518" @default.
- NCIT_C95023 hasExactSynonym "Anti-human GITR Monoclonal Antibody TRX518" @default.
- NCIT_C95023 hasExactSynonym "TRX518" @default.
- NCIT_C95023 inSubset NCIT_C116977 @default.
- NCIT_C95023 inSubset NCIT_C116978 @default.
- NCIT_C95023 inSubset NCIT_C128784 @default.
- NCIT_C95023 inSubset NCIT_C157711 @default.
- NCIT_C95023 inSubset NCIT_C157712 @default.
- NCIT_C95023 inSubset NCIT_C176424 @default.
- NCIT_C95023 inSubset NCIT_C177537 @default.
- NCIT_C95023 type Class @default.
- NCIT_C95023 isDefinedBy ncit.owl @default.
- NCIT_C95023 label "Anti-human GITR Monoclonal Antibody TRX518" @default.
- NCIT_C95023 subClassOf NCIT_C128058 @default.
- NCIT_C95023 subClassOf NCIT_C129820 @default.
- NCIT_C95023 subClassOf NCIT_C129821 @default.
- NCIT_C95023 subClassOf NCIT_C129822 @default.
- NCIT_C95023 subClassOf NCIT_C141144 @default.
- NCIT_C95023 subClassOf NCIT_C1908 @default.
- NCIT_C95023 subClassOf NCIT_C1909 @default.
- NCIT_C95023 subClassOf NCIT_C201119 @default.
- NCIT_C95023 subClassOf NCIT_C20401 @default.
- NCIT_C95023 subClassOf NCIT_C274 @default.
- NCIT_C95023 subClassOf NCIT_C307 @default.
- NCIT_C95023 subClassOf NCIT_C308 @default.
- NCIT_C95023 subClassOf NCIT_C95023 @default.