Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C9506> ?p ?o ?g. }
Showing items 1 to 47 of
47
with 100 items per page.
- NCIT_C9506 IAO_0000115 "A formulated therapeutic oral agent consisting of a combination of the 5-fluorouracil (5-FU) congener prodrug tegafur (tetrahydrofuranyl-5-fluorouracil) and uracil (1:4). The high concentration of uracil reversibly inhibits the uracil-reducing enzyme dihydropyrimidine dehydrogenase (DPD), thereby inhibiting first-pass DPD-mediated hepatic metabolism of the uracil analogue 5-FU and permitting administration of 5-FU as the orally bioavailable prodrug tegafur. Tegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. 5-FU is subsequently converted into its active metabolites 5-fluoro-deoxyuridine-monophosphate (FdUMP) and 5-fluorouridine-triphosphate (FUTP) intracellularly; these metabolites inhibit the enzyme thymidylate synthase and intercalate into RNA, resulting in decreased thymidine synthesis, reduced DNA synthesis, disrupted RNA function, and tumor cell cytotoxicity." @default.
- NCIT_C9506 NCIT_A32 NCIT_C1909 @default.
- NCIT_C9506 NCIT_NHC0 "C9506" @default.
- NCIT_C9506 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C9506 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C9506 NCIT_P108 "Tegafur-Uracil" @default.
- NCIT_C9506 NCIT_P175 "719164" @default.
- NCIT_C9506 NCIT_P207 "C1446539" @default.
- NCIT_C9506 NCIT_P210 "74578-38-4" @default.
- NCIT_C9506 NCIT_P319 "HMI5GR78FR" @default.
- NCIT_C9506 NCIT_P322 "FDA" @default.
- NCIT_C9506 NCIT_P322 "GDC" @default.
- NCIT_C9506 NCIT_P325 "A substance being studied in the treatment of some types of cancer. It is a combination of tegafur and uracil. The tegafur is taken up by the cancer cells and breaks down into 5-FU, a substance that kills tumor cells. The uracil causes higher amounts of 5-FU to stay inside the cells and kill them. Tegafur-uracil is a type of antimetabolite." @default.
- NCIT_C9506 NCIT_P329 "461135" @default.
- NCIT_C9506 NCIT_P330 "461135" @default.
- NCIT_C9506 NCIT_P366 "Tegafur_Uracil" @default.
- NCIT_C9506 NCIT_P375 "Tegafur-Uracil" @default.
- NCIT_C9506 NCIT_P399 "461135" @default.
- NCIT_C9506 normalizedInformationContent "89.350088392419622" @default.
- NCIT_C9506 referenceCount "5" @default.
- NCIT_C9506 hasExactSynonym "Oral Fluorouracil-Uracil" @default.
- NCIT_C9506 hasExactSynonym "TEGAFUR-URACIL" @default.
- NCIT_C9506 hasExactSynonym "Tefudex" @default.
- NCIT_C9506 hasExactSynonym "Tegafur and Uracil" @default.
- NCIT_C9506 hasExactSynonym "Tegafur-Uracil" @default.
- NCIT_C9506 hasExactSynonym "UFT" @default.
- NCIT_C9506 hasExactSynonym "Uftoral" @default.
- NCIT_C9506 hasExactSynonym "Ufur" @default.
- NCIT_C9506 hasExactSynonym "Uracil and Ftorafur" @default.
- NCIT_C9506 hasExactSynonym "Uracil and Tegafur" @default.
- NCIT_C9506 hasExactSynonym "Uracil and Tetrahydrofuranyl-5-Fluorouracil" @default.
- NCIT_C9506 hasExactSynonym "Uracil/Tegafur (UFT)" @default.
- NCIT_C9506 hasExactSynonym "tegafur-uracil" @default.
- NCIT_C9506 inSubset NCIT_C128784 @default.
- NCIT_C9506 inSubset NCIT_C157711 @default.
- NCIT_C9506 inSubset NCIT_C157712 @default.
- NCIT_C9506 inSubset NCIT_C176424 @default.
- NCIT_C9506 inSubset NCIT_C177537 @default.
- NCIT_C9506 inSubset NCIT_C63923 @default.
- NCIT_C9506 type Class @default.
- NCIT_C9506 isDefinedBy ncit.owl @default.
- NCIT_C9506 label "Tegafur-Uracil" @default.
- NCIT_C9506 subClassOf NCIT_C1908 @default.
- NCIT_C9506 subClassOf NCIT_C1909 @default.
- NCIT_C9506 subClassOf NCIT_C2021 @default.
- NCIT_C9506 subClassOf NCIT_C471 @default.
- NCIT_C9506 subClassOf NCIT_C9506 @default.