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- NCIT_C95123 IAO_0000115 "An orally available synthetic mimetic of the growth hormone (GH) secretagogue ghrelin with potential anti-cachexia activity. Upon oral administration, macimorelin mimics endogenous ghrelin by stimulating appetite and binds to the growth hormone secretagogue receptor GHSR in the central nervous system, thereby mimicking the GH-releasing effects of ghrelin from the pituitary gland. Stimulation of GH secretion increases insulin-like growth factor-I (IGF-I) levels which may further stimulate protein synthesis. In addition, ghrelin reduces the production of pro-inflammatory cytokines, which may play a direct role in cancer-related loss of appetite." @default.
- NCIT_C95123 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95123 NCIT_NHC0 "C95123" @default.
- NCIT_C95123 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95123 NCIT_P107 "Macimorelin" @default.
- NCIT_C95123 NCIT_P108 "Macimorelin" @default.
- NCIT_C95123 NCIT_P207 "C2986922" @default.
- NCIT_C95123 NCIT_P210 "381231-18-1" @default.
- NCIT_C95123 NCIT_P319 "8680B21W73" @default.
- NCIT_C95123 NCIT_P322 "CTRP" @default.
- NCIT_C95123 NCIT_P322 "FDA" @default.
- NCIT_C95123 NCIT_P322 "GDC" @default.
- NCIT_C95123 NCIT_P329 "735530" @default.
- NCIT_C95123 NCIT_P330 "735530" @default.
- NCIT_C95123 NCIT_P350 "C26H30N6O3" @default.
- NCIT_C95123 NCIT_P375 "Macimorelin" @default.
- NCIT_C95123 NCIT_P399 "735530" @default.
- NCIT_C95123 normalizedInformationContent "100" @default.
- NCIT_C95123 referenceCount "1" @default.
- NCIT_C95123 hasExactSynonym "AEZS-130" @default.
- NCIT_C95123 hasExactSynonym "D-Tryptophanamide,2-methylalanyl-N-[(1R)-1-(formylamino)-2-(1H-indol-3-yl)ethyl]-" @default.
- NCIT_C95123 hasExactSynonym "EP 1572" @default.
- NCIT_C95123 hasExactSynonym "JMV 1843" @default.
- NCIT_C95123 hasExactSynonym "MACIMORELIN" @default.
- NCIT_C95123 hasExactSynonym "Macimorelin" @default.
- NCIT_C95123 hasExactSynonym "Solorel" @default.
- NCIT_C95123 inSubset NCIT_C116977 @default.
- NCIT_C95123 inSubset NCIT_C116978 @default.
- NCIT_C95123 inSubset NCIT_C128784 @default.
- NCIT_C95123 inSubset NCIT_C157711 @default.
- NCIT_C95123 inSubset NCIT_C157712 @default.
- NCIT_C95123 inSubset NCIT_C176424 @default.
- NCIT_C95123 inSubset NCIT_C177537 @default.
- NCIT_C95123 inSubset NCIT_C63923 @default.
- NCIT_C95123 type Class @default.
- NCIT_C95123 isDefinedBy ncit.owl @default.
- NCIT_C95123 label "Macimorelin" @default.
- NCIT_C95123 subClassOf NCIT_C147908 @default.
- NCIT_C95123 subClassOf NCIT_C1908 @default.
- NCIT_C95123 subClassOf NCIT_C1909 @default.
- NCIT_C95123 subClassOf NCIT_C548 @default.
- NCIT_C95123 subClassOf NCIT_C76358 @default.
- NCIT_C95123 subClassOf NCIT_C95123 @default.