Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C95148> ?p ?o ?g. }
Showing items 1 to 48 of
48
with 100 items per page.
- NCIT_C95148 IAO_0000115 "A small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result, inhibition of DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis. This agent shows a favorable toxicity profile in several aspects: it does not generate reactive oxygen species, as do anthracyclines, hence reducing the risk of cardiotoxicity; it is not a P-glycoprotein (P-gp) substrate, and thereby evades the common mechanism for multidrug resistance; and it has limited distribution to normal tissues and a more chemically stable molecular structure." @default.
- NCIT_C95148 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95148 NCIT_NHC0 "C95148" @default.
- NCIT_C95148 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95148 NCIT_P107 "Vosaroxin" @default.
- NCIT_C95148 NCIT_P108 "Vosaroxin" @default.
- NCIT_C95148 NCIT_P171 "20233886" @default.
- NCIT_C95148 NCIT_P207 "C1451341" @default.
- NCIT_C95148 NCIT_P210 "175414-77-4" @default.
- NCIT_C95148 NCIT_P319 "K6A90IIZ19" @default.
- NCIT_C95148 NCIT_P322 "CTRP" @default.
- NCIT_C95148 NCIT_P322 "FDA" @default.
- NCIT_C95148 NCIT_P322 "GDC" @default.
- NCIT_C95148 NCIT_P329 "393833" @default.
- NCIT_C95148 NCIT_P330 "393833" @default.
- NCIT_C95148 NCIT_P350 "C18H19N5O4S" @default.
- NCIT_C95148 NCIT_P375 "Vosaroxin" @default.
- NCIT_C95148 NCIT_P399 "393833" @default.
- NCIT_C95148 normalizedInformationContent "100" @default.
- NCIT_C95148 referenceCount "1" @default.
- NCIT_C95148 hasExactSynonym "1,4-Dihydro-7-(3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid" @default.
- NCIT_C95148 hasExactSynonym "AG-7352" @default.
- NCIT_C95148 hasExactSynonym "SNS 595" @default.
- NCIT_C95148 hasExactSynonym "SNS-595" @default.
- NCIT_C95148 hasExactSynonym "SPC 595" @default.
- NCIT_C95148 hasExactSynonym "VOSAROXIN" @default.
- NCIT_C95148 hasExactSynonym "Voreloxin" @default.
- NCIT_C95148 hasExactSynonym "Vosaroxin" @default.
- NCIT_C95148 inSubset NCIT_C116977 @default.
- NCIT_C95148 inSubset NCIT_C116978 @default.
- NCIT_C95148 inSubset NCIT_C128784 @default.
- NCIT_C95148 inSubset NCIT_C157711 @default.
- NCIT_C95148 inSubset NCIT_C157712 @default.
- NCIT_C95148 inSubset NCIT_C176424 @default.
- NCIT_C95148 inSubset NCIT_C177537 @default.
- NCIT_C95148 inSubset NCIT_C63923 @default.
- NCIT_C95148 type Class @default.
- NCIT_C95148 isDefinedBy ncit.owl @default.
- NCIT_C95148 label "Vosaroxin" @default.
- NCIT_C95148 subClassOf NCIT_C186664 @default.
- NCIT_C95148 subClassOf NCIT_C1908 @default.
- NCIT_C95148 subClassOf NCIT_C1909 @default.
- NCIT_C95148 subClassOf NCIT_C254 @default.
- NCIT_C95148 subClassOf NCIT_C258 @default.
- NCIT_C95148 subClassOf NCIT_C259 @default.
- NCIT_C95148 subClassOf NCIT_C274 @default.
- NCIT_C95148 subClassOf NCIT_C795 @default.
- NCIT_C95148 subClassOf NCIT_C95148 @default.