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- NCIT_C95202 IAO_0000115 "A synthetic sugar modified heparan sulfate mimetic and agonist of toll-like receptor 9 (TLR9), with potential immunostimulating, antineoplastic and anti-viral activities. Upon administration, pixatimod binds to and activates TLR9 expressed by dendritic cells (DCs) and B-cells. This initiates cytokine release from DCs and activates innate immune signaling pathways, and leads to the activation of natural killer (NK) cells to destroy tumor cells. The combination of pixatimod with certain checkpoint inhibitors may enhance the activation of cytotoxic T-lymphocytes to further kill tumor cells. In addition, pixatimod inhibits the cleavage of heparan sulfate from cell surface proteoglycan by heparanase (HPSE) and inhibits the infiltration of tumor-associated macrophages (TAMs). TLR9, a member of the TLR family, plays a fundamental role in pathogen recognition and activation of innate immunity." @default.
- NCIT_C95202 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95202 NCIT_A7 NCIT_C96048 @default.
- NCIT_C95202 NCIT_NHC0 "C95202" @default.
- NCIT_C95202 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95202 NCIT_P107 "Pixatimod" @default.
- NCIT_C95202 NCIT_P108 "Pixatimod" @default.
- NCIT_C95202 NCIT_P208 "CL426692" @default.
- NCIT_C95202 NCIT_P210 "1144617-49-1" @default.
- NCIT_C95202 NCIT_P319 "66QR34C83N" @default.
- NCIT_C95202 NCIT_P322 "CTRP" @default.
- NCIT_C95202 NCIT_P322 "FDA" @default.
- NCIT_C95202 NCIT_P322 "GDC" @default.
- NCIT_C95202 NCIT_P329 "690742" @default.
- NCIT_C95202 NCIT_P330 "690742" @default.
- NCIT_C95202 NCIT_P375 "Angiogenesis/Heparanase Inhibitor PG545" @default.
- NCIT_C95202 NCIT_P375 "Pixatimod" @default.
- NCIT_C95202 NCIT_P399 "690742" @default.
- NCIT_C95202 normalizedInformationContent "100" @default.
- NCIT_C95202 referenceCount "1" @default.
- NCIT_C95202 hasExactSynonym "PG545" @default.
- NCIT_C95202 hasExactSynonym "PIXATIMOD" @default.
- NCIT_C95202 hasExactSynonym "Pixatimod" @default.
- NCIT_C95202 inSubset NCIT_C116977 @default.
- NCIT_C95202 inSubset NCIT_C116978 @default.
- NCIT_C95202 inSubset NCIT_C128784 @default.
- NCIT_C95202 inSubset NCIT_C157711 @default.
- NCIT_C95202 inSubset NCIT_C157712 @default.
- NCIT_C95202 inSubset NCIT_C176424 @default.
- NCIT_C95202 inSubset NCIT_C177537 @default.
- NCIT_C95202 inSubset NCIT_C63923 @default.
- NCIT_C95202 type Class @default.
- NCIT_C95202 isDefinedBy ncit.owl @default.
- NCIT_C95202 label "Pixatimod" @default.
- NCIT_C95202 subClassOf NCIT_C177174 @default.
- NCIT_C95202 subClassOf NCIT_C177175 @default.
- NCIT_C95202 subClassOf NCIT_C1908 @default.
- NCIT_C95202 subClassOf NCIT_C1909 @default.
- NCIT_C95202 subClassOf NCIT_C2139 @default.
- NCIT_C95202 subClassOf NCIT_C308 @default.
- NCIT_C95202 subClassOf NCIT_C95202 @default.