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- NCIT_C95209 IAO_0000115 "A dinucleotide antimetabolite composed of a decitabine linked via phosphodiester bond to a deoxyguanosine, with potential antineoplastic activity. Following metabolic activation via cleavage of the phosphodiester bond and incorporation of the decitabine moiety into DNA, guadecitabine inhibits DNA methyltransferase, thereby causing non-specific, genome-wide hypomethylation, and induction of cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, which may result in gradual release of decitabine both extra- and intra-cellularly, leading to prolonged exposure to decitabine." @default.
- NCIT_C95209 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95209 NCIT_A7 NCIT_C16508 @default.
- NCIT_C95209 NCIT_NHC0 "C95209" @default.
- NCIT_C95209 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C95209 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95209 NCIT_P107 "Guadecitabine" @default.
- NCIT_C95209 NCIT_P108 "Guadecitabine" @default.
- NCIT_C95209 NCIT_P207 "C2986994" @default.
- NCIT_C95209 NCIT_P210 "929901-49-5" @default.
- NCIT_C95209 NCIT_P319 "2KT4YN1DP7" @default.
- NCIT_C95209 NCIT_P322 "CTRP" @default.
- NCIT_C95209 NCIT_P322 "FDA" @default.
- NCIT_C95209 NCIT_P322 "GDC" @default.
- NCIT_C95209 NCIT_P329 "691684" @default.
- NCIT_C95209 NCIT_P330 "691684" @default.
- NCIT_C95209 NCIT_P375 "Guadecitabine" @default.
- NCIT_C95209 NCIT_P399 "691684" @default.
- NCIT_C95209 normalizedInformationContent "100" @default.
- NCIT_C95209 referenceCount "1" @default.
- NCIT_C95209 hasExactSynonym "DNMT inhibitor SGI-110" @default.
- NCIT_C95209 hasExactSynonym "GUADECITABINE" @default.
- NCIT_C95209 hasExactSynonym "Guadecitabine" @default.
- NCIT_C95209 hasExactSynonym "S110" @default.
- NCIT_C95209 hasExactSynonym "SGI-110" @default.
- NCIT_C95209 inSubset NCIT_C116977 @default.
- NCIT_C95209 inSubset NCIT_C116978 @default.
- NCIT_C95209 inSubset NCIT_C128784 @default.
- NCIT_C95209 inSubset NCIT_C157711 @default.
- NCIT_C95209 inSubset NCIT_C157712 @default.
- NCIT_C95209 inSubset NCIT_C176424 @default.
- NCIT_C95209 inSubset NCIT_C177537 @default.
- NCIT_C95209 inSubset NCIT_C63923 @default.
- NCIT_C95209 type Class @default.
- NCIT_C95209 isDefinedBy ncit.owl @default.
- NCIT_C95209 label "Guadecitabine" @default.
- NCIT_C95209 subClassOf NCIT_C132686 @default.
- NCIT_C95209 subClassOf NCIT_C1908 @default.
- NCIT_C95209 subClassOf NCIT_C1909 @default.
- NCIT_C95209 subClassOf NCIT_C2083 @default.
- NCIT_C95209 subClassOf NCIT_C274 @default.
- NCIT_C95209 subClassOf NCIT_C471 @default.
- NCIT_C95209 subClassOf NCIT_C95209 @default.