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- NCIT_C95210 IAO_0000115 "A synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase). Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA), therefore the patient is less likely to have a relapse after treatment is discontinued." @default.
- NCIT_C95210 NCIT_NHC0 "C95210" @default.
- NCIT_C95210 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C95210 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95210 NCIT_P108 "Clevudine" @default.
- NCIT_C95210 NCIT_P207 "C0045212" @default.
- NCIT_C95210 NCIT_P210 "163252-36-6" @default.
- NCIT_C95210 NCIT_P319 "IN51MVP5F1" @default.
- NCIT_C95210 NCIT_P322 "FDA" @default.
- NCIT_C95210 NCIT_P329 "691979" @default.
- NCIT_C95210 NCIT_P330 "691979" @default.
- NCIT_C95210 NCIT_P350 "C10H13FN2O5" @default.
- NCIT_C95210 NCIT_P399 "691979" @default.
- NCIT_C95210 normalizedInformationContent "100" @default.
- NCIT_C95210 referenceCount "1" @default.
- NCIT_C95210 hasExactSynonym "1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione" @default.
- NCIT_C95210 hasExactSynonym "1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)thymine" @default.
- NCIT_C95210 hasExactSynonym "2'-Fluoro-5-methyl-beta-L-arabinofuranosyluracil" @default.
- NCIT_C95210 hasExactSynonym "CLEVUDINE" @default.
- NCIT_C95210 hasExactSynonym "Clevudine" @default.
- NCIT_C95210 hasExactSynonym "L-FMAU" @default.
- NCIT_C95210 hasExactSynonym "Levovir" @default.
- NCIT_C95210 hasExactSynonym "Revovir" @default.
- NCIT_C95210 inSubset NCIT_C173381 @default.
- NCIT_C95210 inSubset NCIT_C173383 @default.
- NCIT_C95210 inSubset NCIT_C176424 @default.
- NCIT_C95210 inSubset NCIT_C63923 @default.
- NCIT_C95210 type Class @default.
- NCIT_C95210 isDefinedBy ncit.owl @default.
- NCIT_C95210 label "Clevudine" @default.
- NCIT_C95210 subClassOf NCIT_C1908 @default.
- NCIT_C95210 subClassOf NCIT_C1909 @default.
- NCIT_C95210 subClassOf NCIT_C254 @default.
- NCIT_C95210 subClassOf NCIT_C281 @default.
- NCIT_C95210 subClassOf NCIT_C29575 @default.
- NCIT_C95210 subClassOf NCIT_C471 @default.
- NCIT_C95210 subClassOf NCIT_C95210 @default.