Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C95223> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- NCIT_C95223 IAO_0000115 "The hydrochloride salt of nilotinib, an orally bioavailable aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. Designed to overcome imatinib resistance, nilotinib binds to and stabilizes the inactive conformation of the kinase domain of the Abl protein of the Bcr-Abl fusion protein, resulting in the inhibition of the Bcr-Abl-mediated proliferation of Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) cells. This agent also inhibits the receptor tyrosine kinases platelet-derived growth factor receptor (PDGF-R) and c-kit, a receptor tyrosine kinase mutated and constitutively activated in most gastrointestinal stromal tumors (GISTs). With a binding mode that is energetically more favorable than that of imatinib, nilotinib has been shown to have an approximately 20-fold increased potency in kinase and proliferation assays compared to imatinib." @default.
- NCIT_C95223 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95223 NCIT_A6 NCIT_C48375 @default.
- NCIT_C95223 NCIT_NHC0 "C95223" @default.
- NCIT_C95223 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95223 NCIT_P108 "Nilotinib Hydrochloride Anhydrous" @default.
- NCIT_C95223 NCIT_P207 "C2987005" @default.
- NCIT_C95223 NCIT_P210 "923288-95-3" @default.
- NCIT_C95223 NCIT_P319 "K37N7BYX3X" @default.
- NCIT_C95223 NCIT_P322 "FDA" @default.
- NCIT_C95223 NCIT_P322 "GDC" @default.
- NCIT_C95223 NCIT_P350 "C28H22F3N7O.HCl" @default.
- NCIT_C95223 NCIT_P375 "Nilotinib Hydrochloride Anhydrous" @default.
- NCIT_C95223 NCIT_R124 NCIT_C17828 @default.
- NCIT_C95223 NCIT_R124 NCIT_C18992 @default.
- NCIT_C95223 NCIT_R124 NCIT_C19143 @default.
- NCIT_C95223 NCIT_R124 NCIT_C21124 @default.
- NCIT_C95223 NCIT_R124 NCIT_C40702 @default.
- NCIT_C95223 NCIT_R124 NCIT_C40703 @default.
- NCIT_C95223 NCIT_R124 NCIT_C40704 @default.
- NCIT_C95223 NCIT_R125 NCIT_C17133 @default.
- NCIT_C95223 NCIT_R125 NCIT_C17828 @default.
- NCIT_C95223 NCIT_R125 NCIT_C18081 @default.
- NCIT_C95223 NCIT_R125 NCIT_C20150 @default.
- NCIT_C95223 NCIT_R125 NCIT_C20480 @default.
- NCIT_C95223 NCIT_R125 NCIT_C20751 @default.
- NCIT_C95223 NCIT_R125 NCIT_C40715 @default.
- NCIT_C95223 NCIT_R125 NCIT_C40821 @default.
- NCIT_C95223 NCIT_R125 NCIT_C41515 @default.
- NCIT_C95223 NCIT_R125 NCIT_C51037 @default.
- NCIT_C95223 NCIT_R146 NCIT_C16325 @default.
- NCIT_C95223 NCIT_R146 NCIT_C16554 @default.
- NCIT_C95223 NCIT_R146 NCIT_C16934 @default.
- NCIT_C95223 NCIT_R146 NCIT_C16984 @default.
- NCIT_C95223 NCIT_R146 NCIT_C17018 @default.
- NCIT_C95223 NCIT_R146 NCIT_C17020 @default.
- NCIT_C95223 NCIT_R146 NCIT_C17021 @default.
- NCIT_C95223 NCIT_R146 NCIT_C17210 @default.
- NCIT_C95223 NCIT_R146 NCIT_C17561 @default.
- NCIT_C95223 NCIT_R146 NCIT_C17660 @default.
- NCIT_C95223 NCIT_R146 NCIT_C17728 @default.
- NCIT_C95223 NCIT_R146 NCIT_C18106 @default.
- NCIT_C95223 NCIT_R146 NCIT_C20027 @default.
- NCIT_C95223 NCIT_R146 NCIT_C20032 @default.
- NCIT_C95223 NCIT_R146 NCIT_C26548 @default.
- NCIT_C95223 normalizedInformationContent "100" @default.
- NCIT_C95223 referenceCount "1" @default.
- NCIT_C95223 hasExactSynonym "NILOTINIB HYDROCHLORIDE ANHYDROUS" @default.
- NCIT_C95223 hasExactSynonym "Nilotinib Hydrochloride Anhydrous" @default.
- NCIT_C95223 inSubset NCIT_C128784 @default.
- NCIT_C95223 inSubset NCIT_C157711 @default.
- NCIT_C95223 inSubset NCIT_C157712 @default.
- NCIT_C95223 inSubset NCIT_C177537 @default.
- NCIT_C95223 inSubset NCIT_C63923 @default.
- NCIT_C95223 type Class @default.
- NCIT_C95223 isDefinedBy ncit.owl @default.
- NCIT_C95223 label "Nilotinib Hydrochloride Anhydrous" @default.
- NCIT_C95223 subClassOf B26a2712bfd40f0e271e87bf1b40b2a32 @default.
- NCIT_C95223 subClassOf B453b17c90a2a4b7a2103e2637428aba1 @default.
- NCIT_C95223 subClassOf B4efa17c682ddfa4f36650744a0b941ab @default.
- NCIT_C95223 subClassOf B521adeb61f55c9f5ec88652a6aa5198a @default.
- NCIT_C95223 subClassOf B61ca8e6b673c21e30c2c1a95f78d8281 @default.
- NCIT_C95223 subClassOf B700c88d9bbbdd1a8fb4c7f12670b3668 @default.
- NCIT_C95223 subClassOf B819da66f726658b961d391d6446ce7ff @default.
- NCIT_C95223 subClassOf B8f528434cc79b6024031c0b8c579bc26 @default.
- NCIT_C95223 subClassOf Badc4a291262f726a830a6db110f9f5da @default.
- NCIT_C95223 subClassOf Bb3b98059ebb4078bd02003e028a59056 @default.
- NCIT_C95223 subClassOf Bb4014a8e34b9f4846fc336a227a6e099 @default.
- NCIT_C95223 subClassOf Be18fbc056829dba1c740b442c4aabccc @default.
- NCIT_C95223 subClassOf NCIT_C129824 @default.
- NCIT_C95223 subClassOf NCIT_C129825 @default.
- NCIT_C95223 subClassOf NCIT_C1404 @default.
- NCIT_C95223 subClassOf NCIT_C155700 @default.
- NCIT_C95223 subClassOf NCIT_C159198 @default.
- NCIT_C95223 subClassOf NCIT_C159199 @default.
- NCIT_C95223 subClassOf NCIT_C163758 @default.
- NCIT_C95223 subClassOf NCIT_C163999 @default.
- NCIT_C95223 subClassOf NCIT_C164037 @default.
- NCIT_C95223 subClassOf NCIT_C1908 @default.
- NCIT_C95223 subClassOf NCIT_C1909 @default.
- NCIT_C95223 subClassOf NCIT_C1967 @default.
- NCIT_C95223 subClassOf NCIT_C2189 @default.
- NCIT_C95223 subClassOf NCIT_C274 @default.
- NCIT_C95223 subClassOf NCIT_C471 @default.
- NCIT_C95223 subClassOf NCIT_C95223 @default.