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- NCIT_C95225 IAO_0000115 "The sulfate salt of selumetinib, an orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers." @default.
- NCIT_C95225 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95225 NCIT_A6 NCIT_C66939 @default.
- NCIT_C95225 NCIT_A7 NCIT_C26486 @default.
- NCIT_C95225 NCIT_NHC0 "C95225" @default.
- NCIT_C95225 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95225 NCIT_P107 "Selumetinib Sulfate" @default.
- NCIT_C95225 NCIT_P108 "Selumetinib Sulfate" @default.
- NCIT_C95225 NCIT_P207 "C2987007" @default.
- NCIT_C95225 NCIT_P210 "943332-08-9" @default.
- NCIT_C95225 NCIT_P302 "pediatric patients, 2 years of age and older, with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas (PN)." @default.
- NCIT_C95225 NCIT_P319 "807ME4B7IJ" @default.
- NCIT_C95225 NCIT_P322 "CTRP" @default.
- NCIT_C95225 NCIT_P322 "FDA" @default.
- NCIT_C95225 NCIT_P322 "GDC" @default.
- NCIT_C95225 NCIT_P329 "532294" @default.
- NCIT_C95225 NCIT_P330 "532294" @default.
- NCIT_C95225 NCIT_P350 "C17H15BrClFN4O3.H2O4S" @default.
- NCIT_C95225 NCIT_P375 "Selumetinib Sulfate" @default.
- NCIT_C95225 NCIT_P399 "532294" @default.
- NCIT_C95225 NCIT_R124 NCIT_C17710 @default.
- NCIT_C95225 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C95225 NCIT_R125 NCIT_C20480 @default.
- NCIT_C95225 NCIT_R125 NCIT_C20751 @default.
- NCIT_C95225 NCIT_R146 NCIT_C16554 @default.
- NCIT_C95225 NCIT_R146 NCIT_C16984 @default.
- NCIT_C95225 NCIT_R146 NCIT_C17018 @default.
- NCIT_C95225 NCIT_R146 NCIT_C17021 @default.
- NCIT_C95225 NCIT_R146 NCIT_C17210 @default.
- NCIT_C95225 NCIT_R146 NCIT_C17325 @default.
- NCIT_C95225 NCIT_R146 NCIT_C20027 @default.
- NCIT_C95225 NCIT_R146 NCIT_C26486 @default.
- NCIT_C95225 NCIT_R146 NCIT_C26548 @default.
- NCIT_C95225 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C95225 referenceCount "2" @default.
- NCIT_C95225 hasExactSynonym "1H-Benzimidazole-6-Carboxamide, 5-((4-Bromo-2-Chlorophenyl)Amino)-4-Fluoro-N-(2- Hydroxyethoxy)-1-Methyl-, Sulfate (1:1)" @default.
- NCIT_C95225 hasExactSynonym "1h-Benzimidazole-6-Carboxamide,5-((4-Bromo-2-Chlorophenyl)Amino)-4-Fluoro-N-(2- Hydroxyethoxy)-1-Methyl-, Sulphate (1:1)" @default.
- NCIT_C95225 hasExactSynonym "5-((4-Bromo-2-Chlorophenyl)amino)-4-Fluoro-N-(2-Hydroxyethoxy)-1-Methyl-1H- Benzimidazole-6-Carboxamide Sulfate" @default.
- NCIT_C95225 hasExactSynonym "5-((4-Bromo-2-Chlorophenyl)amino)-4-Fluoro-N-(2-Hydroxyethoxy)-1-Methyl-1H- Benzimidazole-6-Carboxamide Sulphate" @default.
- NCIT_C95225 hasExactSynonym "AZD-6244 Hydrogen Sulfate" @default.
- NCIT_C95225 hasExactSynonym "AZD6244 Hydrogen Sulfate" @default.
- NCIT_C95225 hasExactSynonym "AZD6244 Hydrogen Sulphate" @default.
- NCIT_C95225 hasExactSynonym "Koselugo" @default.
- NCIT_C95225 hasExactSynonym "SELUMETINIB SULFATE" @default.
- NCIT_C95225 hasExactSynonym "Selumetinib Sulfate" @default.
- NCIT_C95225 hasExactSynonym "Selumetinib Sulphate" @default.
- NCIT_C95225 inSubset NCIT_C116977 @default.
- NCIT_C95225 inSubset NCIT_C116978 @default.
- NCIT_C95225 inSubset NCIT_C128784 @default.
- NCIT_C95225 inSubset NCIT_C157711 @default.
- NCIT_C95225 inSubset NCIT_C157712 @default.
- NCIT_C95225 inSubset NCIT_C176424 @default.
- NCIT_C95225 inSubset NCIT_C177537 @default.
- NCIT_C95225 inSubset NCIT_C63923 @default.
- NCIT_C95225 type Class @default.
- NCIT_C95225 isDefinedBy ncit.owl @default.
- NCIT_C95225 label "Selumetinib Sulfate" @default.
- NCIT_C95225 subClassOf B0da19e334439853554dafe2503108fa8 @default.
- NCIT_C95225 subClassOf B27d22eaa3d749a6a86e202314893fe80 @default.
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- NCIT_C95225 subClassOf NCIT_C1404 @default.
- NCIT_C95225 subClassOf NCIT_C163758 @default.
- NCIT_C95225 subClassOf NCIT_C1908 @default.
- NCIT_C95225 subClassOf NCIT_C1909 @default.
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- NCIT_C95225 subClassOf NCIT_C274 @default.
- NCIT_C95225 subClassOf NCIT_C471 @default.
- NCIT_C95225 subClassOf NCIT_C69145 @default.
- NCIT_C95225 subClassOf NCIT_C95225 @default.