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- NCIT_C95226 IAO_0000115 "The tosylate salt form of varlitinib, an orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types. Due to the dual inhibition of both EGFR and Her-2, this agent may be therapeutically more effective than agents that inhibit EGFR or Her-2 alone." @default.
- NCIT_C95226 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95226 NCIT_A6 NCIT_C62530 @default.
- NCIT_C95226 NCIT_A7 NCIT_C17068 @default.
- NCIT_C95226 NCIT_NHC0 "C95226" @default.
- NCIT_C95226 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95226 NCIT_P108 "Varlitinib Tosylate" @default.
- NCIT_C95226 NCIT_P207 "C2987008" @default.
- NCIT_C95226 NCIT_P210 "1146629-86-8" @default.
- NCIT_C95226 NCIT_P319 "V4M8FWS152" @default.
- NCIT_C95226 NCIT_P322 "FDA" @default.
- NCIT_C95226 NCIT_P322 "GDC" @default.
- NCIT_C95226 NCIT_P329 "793457" @default.
- NCIT_C95226 NCIT_P330 "793457" @default.
- NCIT_C95226 NCIT_P350 "C22H19ClN6O2S.2C7H8O3S" @default.
- NCIT_C95226 NCIT_P375 "Varlitinib Tosylate" @default.
- NCIT_C95226 NCIT_P399 "793457" @default.
- NCIT_C95226 NCIT_R124 NCIT_C17828 @default.
- NCIT_C95226 NCIT_R124 NCIT_C18992 @default.
- NCIT_C95226 NCIT_R124 NCIT_C19143 @default.
- NCIT_C95226 NCIT_R124 NCIT_C21124 @default.
- NCIT_C95226 NCIT_R124 NCIT_C40702 @default.
- NCIT_C95226 NCIT_R124 NCIT_C40703 @default.
- NCIT_C95226 NCIT_R124 NCIT_C40704 @default.
- NCIT_C95226 NCIT_R125 NCIT_C17133 @default.
- NCIT_C95226 NCIT_R125 NCIT_C17710 @default.
- NCIT_C95226 NCIT_R125 NCIT_C17828 @default.
- NCIT_C95226 NCIT_R125 NCIT_C18081 @default.
- NCIT_C95226 NCIT_R125 NCIT_C20480 @default.
- NCIT_C95226 NCIT_R125 NCIT_C20751 @default.
- NCIT_C95226 NCIT_R125 NCIT_C28498 @default.
- NCIT_C95226 NCIT_R125 NCIT_C40576 @default.
- NCIT_C95226 NCIT_R125 NCIT_C40577 @default.
- NCIT_C95226 NCIT_R125 NCIT_C40821 @default.
- NCIT_C95226 normalizedInformationContent "100" @default.
- NCIT_C95226 referenceCount "1" @default.
- NCIT_C95226 hasExactSynonym "4,6-Quinazolinediamine, N(Sup 4)-(3-Chloro-4-(2-Thiazolylmethoxy)Phenyl)-N(Sup 6)-((4r)-4,5-Dihydro-4-Methyl-2-Oxazolyl)-, 4-Methylbenzenesulphonate (1:2)" @default.
- NCIT_C95226 hasExactSynonym "4-N-(3-Chloro-4-(Thiazol-2-Ylmethoxy)Phenyl)-6-N-((4r)-4-Methyl-4,5-Dihydrooxazol-2- Yl)Quinazoline-4,6-Diamine Bis(4-Methylbenzenesulphonate)" @default.
- NCIT_C95226 hasExactSynonym "AR00334543 Ditosilate" @default.
- NCIT_C95226 hasExactSynonym "AR00334543 Ditosylate" @default.
- NCIT_C95226 hasExactSynonym "ARRY-334543 Ditosylate" @default.
- NCIT_C95226 hasExactSynonym "ARRY-543 Ditosilate" @default.
- NCIT_C95226 hasExactSynonym "ARRY-543 Ditosylate" @default.
- NCIT_C95226 hasExactSynonym "VARLITINIB TOSYLATE" @default.
- NCIT_C95226 hasExactSynonym "Varlitinib Tosylate" @default.
- NCIT_C95226 inSubset NCIT_C128784 @default.
- NCIT_C95226 inSubset NCIT_C157711 @default.
- NCIT_C95226 inSubset NCIT_C157712 @default.
- NCIT_C95226 inSubset NCIT_C176424 @default.
- NCIT_C95226 inSubset NCIT_C177537 @default.
- NCIT_C95226 inSubset NCIT_C63923 @default.
- NCIT_C95226 type Class @default.
- NCIT_C95226 isDefinedBy ncit.owl @default.
- NCIT_C95226 label "Varlitinib Tosylate" @default.
- NCIT_C95226 subClassOf B0dded1d2add67ba763b127842ff08cf2 @default.
- NCIT_C95226 subClassOf B0ef773d89898926fd2fa059be536fb56 @default.
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- NCIT_C95226 subClassOf B79299bfbe0a9cefe7f37532a9b2cab30 @default.
- NCIT_C95226 subClassOf B9b8ef3ce25e9a135ded321d057a1fea7 @default.
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- NCIT_C95226 subClassOf Bb83e8002074672a8578dc1f01c044b0a @default.
- NCIT_C95226 subClassOf NCIT_C129824 @default.
- NCIT_C95226 subClassOf NCIT_C129825 @default.
- NCIT_C95226 subClassOf NCIT_C1404 @default.
- NCIT_C95226 subClassOf NCIT_C163758 @default.
- NCIT_C95226 subClassOf NCIT_C163952 @default.
- NCIT_C95226 subClassOf NCIT_C1908 @default.
- NCIT_C95226 subClassOf NCIT_C1909 @default.
- NCIT_C95226 subClassOf NCIT_C1967 @default.
- NCIT_C95226 subClassOf NCIT_C2167 @default.
- NCIT_C95226 subClassOf NCIT_C2189 @default.
- NCIT_C95226 subClassOf NCIT_C274 @default.
- NCIT_C95226 subClassOf NCIT_C471 @default.
- NCIT_C95226 subClassOf NCIT_C95226 @default.