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- NCIT_C95229 IAO_0000115 "The monohydrate monohydrochloride form of nilotinib, an orally bioavailable aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. Designed to overcome imatinib resistance resulting from Bcr-Abl kinase mutations, upon administration, nilotinib binds to and stabilizes the inactive conformation of the kinase domain of the Abl portion of the Bcr-Abl fusion protein, resulting in the inhibition of the constitutive kinase activity of Bcr-Abl protein. This inhibits the Bcr-Abl-mediated proliferation of Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) cells. Nilotinib also inhibits the receptor tyrosine kinases platelet-derived growth factor receptor (PDGF-R; PDGFR), mast/stem cell growth factor receptor Kit (c-Kit), and, to a lesser extent, colony-stimulating factor 1 receptor (CSF-1R; CSF1R), and discoidin domain-containing receptor 1 (DDR1)." @default.
- NCIT_C95229 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95229 NCIT_A6 NCIT_C48375 @default.
- NCIT_C95229 NCIT_NHC0 "C95229" @default.
- NCIT_C95229 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95229 NCIT_P107 "Nilotinib Hydrochloride Monohydrate" @default.
- NCIT_C95229 NCIT_P108 "Nilotinib Hydrochloride Monohydrate" @default.
- NCIT_C95229 NCIT_P207 "C1966375" @default.
- NCIT_C95229 NCIT_P210 "923288-90-8" @default.
- NCIT_C95229 NCIT_P302 "Chronic myeloid leukemia; Philadelphia chromosome-positive acute lymphoblastic leukemia" @default.
- NCIT_C95229 NCIT_P319 "5JHU0N1R6K" @default.
- NCIT_C95229 NCIT_P322 "CTRP" @default.
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- NCIT_C95229 NCIT_P329 "435988" @default.
- NCIT_C95229 NCIT_P330 "435988" @default.
- NCIT_C95229 NCIT_P350 "C28H22F3N7O.HCl.H2O" @default.
- NCIT_C95229 NCIT_P375 "Nilotinib Hydrochloride Monohydrate" @default.
- NCIT_C95229 NCIT_P399 "435988" @default.
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- NCIT_C95229 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C95229 referenceCount "2" @default.
- NCIT_C95229 hasExactSynonym "4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzamide, Monohydrochloride" @default.
- NCIT_C95229 hasExactSynonym "AMN107" @default.
- NCIT_C95229 hasExactSynonym "NILOTINIB HYDROCHLORIDE MONOHYDRATE" @default.
- NCIT_C95229 hasExactSynonym "Nilotinib Hydrochloride Monohydrate" @default.
- NCIT_C95229 hasExactSynonym "Nilotinib Monohydrochloride Monohydrate" @default.
- NCIT_C95229 hasExactSynonym "Tasigna" @default.
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- NCIT_C95229 type Class @default.
- NCIT_C95229 isDefinedBy ncit.owl @default.
- NCIT_C95229 label "Nilotinib Hydrochloride Monohydrate" @default.
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