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- NCIT_C95699 IAO_0000115 "The tosylate salt form of ANA773, a Toll-Like Receptor 7 (TLR7) agonist prodrug with potential immunostimulating activity. Upon oral administration, ANA773 is metabolized into its active form that binds to and activates TLR7, thereby stimulating dendritic cells (DCs) and enhancing natural killer cell (NK) cytotoxicity. This activation results in the production of proinflammatory cytokines, including interferon alpha, and enhanced antibody-dependent cellular cytotoxicity (ADCC). TLR7 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity." @default.
- NCIT_C95699 NCIT_A7 NCIT_C30108 @default.
- NCIT_C95699 NCIT_NHC0 "C95699" @default.
- NCIT_C95699 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95699 NCIT_P107 "TLR7 Agonist ANA773 Tosylate" @default.
- NCIT_C95699 NCIT_P108 "TLR7 Agonist ANA773 Tosylate" @default.
- NCIT_C95699 NCIT_P208 "CL428165" @default.
- NCIT_C95699 NCIT_P322 "CTRP" @default.
- NCIT_C95699 NCIT_P329 "689123" @default.
- NCIT_C95699 NCIT_P330 "689123" @default.
- NCIT_C95699 NCIT_P399 "689123" @default.
- NCIT_C95699 normalizedInformationContent "100" @default.
- NCIT_C95699 referenceCount "1" @default.
- NCIT_C95699 hasExactSynonym "ANA773 Tosylate" @default.
- NCIT_C95699 hasExactSynonym "TLR7 Agonist ANA773 Tosylate" @default.
- NCIT_C95699 hasExactSynonym "Toll-Like Receptor 7 Agonist ANA773 Tosylate" @default.
- NCIT_C95699 inSubset NCIT_C116977 @default.
- NCIT_C95699 inSubset NCIT_C116978 @default.
- NCIT_C95699 inSubset NCIT_C176424 @default.
- NCIT_C95699 type Class @default.
- NCIT_C95699 isDefinedBy ncit.owl @default.
- NCIT_C95699 label "TLR7 Agonist ANA773 Tosylate" @default.
- NCIT_C95699 subClassOf NCIT_C177174 @default.
- NCIT_C95699 subClassOf NCIT_C177176 @default.
- NCIT_C95699 subClassOf NCIT_C1908 @default.
- NCIT_C95699 subClassOf NCIT_C1909 @default.
- NCIT_C95699 subClassOf NCIT_C2139 @default.
- NCIT_C95699 subClassOf NCIT_C308 @default.
- NCIT_C95699 subClassOf NCIT_C95699 @default.