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- NCIT_C95701 IAO_0000115 "An orally available cyclin-dependent kinase (CDK) inhibitor targets at cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Ribociclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation." @default.
- NCIT_C95701 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95701 NCIT_A7 NCIT_C17680 @default.
- NCIT_C95701 NCIT_A7 NCIT_C97386 @default.
- NCIT_C95701 NCIT_NHC0 "C95701" @default.
- NCIT_C95701 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95701 NCIT_P107 "Ribociclib" @default.
- NCIT_C95701 NCIT_P108 "Ribociclib" @default.
- NCIT_C95701 NCIT_P207 "C4045494" @default.
- NCIT_C95701 NCIT_P210 "1211441-98-3" @default.
- NCIT_C95701 NCIT_P302 "breast cancer" @default.
- NCIT_C95701 NCIT_P319 "TK8ERE8P56" @default.
- NCIT_C95701 NCIT_P322 "CTRP" @default.
- NCIT_C95701 NCIT_P322 "FDA" @default.
- NCIT_C95701 NCIT_P322 "GDC" @default.
- NCIT_C95701 NCIT_P329 "689330" @default.
- NCIT_C95701 NCIT_P330 "689330" @default.
- NCIT_C95701 NCIT_P375 "Ribociclib" @default.
- NCIT_C95701 NCIT_P399 "689330" @default.
- NCIT_C95701 normalizedInformationContent "88.143637090998837" @default.
- NCIT_C95701 referenceCount "6" @default.
- NCIT_C95701 hasExactSynonym "7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide" @default.
- NCIT_C95701 hasExactSynonym "Kisqali" @default.
- NCIT_C95701 hasExactSynonym "LEE-011" @default.
- NCIT_C95701 hasExactSynonym "LEE011" @default.
- NCIT_C95701 hasExactSynonym "RIBOCICLIB" @default.
- NCIT_C95701 hasExactSynonym "Ribociclib" @default.
- NCIT_C95701 inSubset NCIT_C116977 @default.
- NCIT_C95701 inSubset NCIT_C116978 @default.
- NCIT_C95701 inSubset NCIT_C128784 @default.
- NCIT_C95701 inSubset NCIT_C157711 @default.
- NCIT_C95701 inSubset NCIT_C157712 @default.
- NCIT_C95701 inSubset NCIT_C176424 @default.
- NCIT_C95701 inSubset NCIT_C177537 @default.
- NCIT_C95701 inSubset NCIT_C63923 @default.
- NCIT_C95701 type Class @default.
- NCIT_C95701 isDefinedBy ncit.owl @default.
- NCIT_C95701 label "Ribociclib" @default.
- NCIT_C95701 subClassOf NCIT_C129824 @default.
- NCIT_C95701 subClassOf NCIT_C129825 @default.
- NCIT_C95701 subClassOf NCIT_C1404 @default.
- NCIT_C95701 subClassOf NCIT_C163758 @default.
- NCIT_C95701 subClassOf NCIT_C1908 @default.
- NCIT_C95701 subClassOf NCIT_C1909 @default.
- NCIT_C95701 subClassOf NCIT_C192741 @default.
- NCIT_C95701 subClassOf NCIT_C192742 @default.
- NCIT_C95701 subClassOf NCIT_C2185 @default.
- NCIT_C95701 subClassOf NCIT_C2189 @default.
- NCIT_C95701 subClassOf NCIT_C274 @default.
- NCIT_C95701 subClassOf NCIT_C471 @default.
- NCIT_C95701 subClassOf NCIT_C61074 @default.
- NCIT_C95701 subClassOf NCIT_C95701 @default.