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- NCIT_C95709 IAO_0000115 "A chimeric, 25-mer peptide that targets prohibitin, with potential antineoplastic activity. Prohibitin-targeting peptide 1 (prohibitin-TP01) consists of a fat-targeting motif (CKGGRAKDC), two repeats of a proapoptotic peptide motif (KLAKLAK) and a GG linker. This peptide binds specifically to prohibitin in the white adipose vasculature; upon receptor-mediated cell internalization, the ligand/receptor complex triggers apoptosis and results in ablation of white fat. Destruction of white fat may potentially have positive consequences for men with prostate cancer since a high level of white fat has been implicated as a critical contributing factor in poor prostate cancer outcome. Prohibitin, a multifunctional membrane-associated protein that is thought to regulate cell survival and growth, has been shown by immunohistochemical analysis to be expressed in the membrane of endothelial cells in white adipose tissue." @default.
- NCIT_C95709 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95709 NCIT_A7 NCIT_C21207 @default.
- NCIT_C95709 NCIT_NHC0 "C95709" @default.
- NCIT_C95709 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C95709 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95709 NCIT_P107 "Prohibitin-Targeting Peptide 1" @default.
- NCIT_C95709 NCIT_P108 "Prohibitin-Targeting Peptide 1" @default.
- NCIT_C95709 NCIT_P171 "15133506" @default.
- NCIT_C95709 NCIT_P208 "CL428174" @default.
- NCIT_C95709 NCIT_P322 "CTRP" @default.
- NCIT_C95709 NCIT_P322 "GDC" @default.
- NCIT_C95709 NCIT_P329 "691802" @default.
- NCIT_C95709 NCIT_P330 "691802" @default.
- NCIT_C95709 NCIT_P375 "Prohibitin-Targeting Peptide 1" @default.
- NCIT_C95709 NCIT_P399 "691802" @default.
- NCIT_C95709 normalizedInformationContent "100" @default.
- NCIT_C95709 referenceCount "1" @default.
- NCIT_C95709 hasExactSynonym "Prohibitin-TP01" @default.
- NCIT_C95709 hasExactSynonym "Prohibitin-Targeting Peptide 1" @default.
- NCIT_C95709 hasExactSynonym "TP01" @default.
- NCIT_C95709 inSubset NCIT_C116977 @default.
- NCIT_C95709 inSubset NCIT_C116978 @default.
- NCIT_C95709 inSubset NCIT_C128784 @default.
- NCIT_C95709 inSubset NCIT_C157711 @default.
- NCIT_C95709 inSubset NCIT_C157712 @default.
- NCIT_C95709 inSubset NCIT_C176424 @default.
- NCIT_C95709 inSubset NCIT_C177537 @default.
- NCIT_C95709 type Class @default.
- NCIT_C95709 isDefinedBy ncit.owl @default.
- NCIT_C95709 label "Prohibitin-Targeting Peptide 1" @default.
- NCIT_C95709 subClassOf NCIT_C129824 @default.
- NCIT_C95709 subClassOf NCIT_C1908 @default.
- NCIT_C95709 subClassOf NCIT_C1909 @default.
- NCIT_C95709 subClassOf NCIT_C2189 @default.
- NCIT_C95709 subClassOf NCIT_C274 @default.
- NCIT_C95709 subClassOf NCIT_C95709 @default.