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- NCIT_C95710 IAO_0000115 "An antibody-drug conjugate (ADC) containing labetuzumab, a mildly reduced, anti-CEACAM5 humanized monoclonal antibody, conjugated to the potent topoisomerase I inhibitor SN-38, with antineoplastic activity. The monoclonal antibody moiety of labetuzumab govitecan selectively binds to carcinoembryonic cell adhesion molecule 5 (CEACAM5), which is abundantly expressed on the surface of a majority of solid tumors. Upon internalization and proteolytic cleavage, SN-38, the active metabolite of irinotecan, inhibits the activity of topoisomerase I in the tumor cells, eventually inhibiting both DNA replication and transcription and leading to tumor cell apoptosis." @default.
- NCIT_C95710 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95710 NCIT_A7 NCIT_C16384 @default.
- NCIT_C95710 NCIT_NHC0 "C95710" @default.
- NCIT_C95710 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C95710 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95710 NCIT_P107 "Labetuzumab Govitecan" @default.
- NCIT_C95710 NCIT_P108 "Labetuzumab Govitecan" @default.
- NCIT_C95710 NCIT_P208 "CL428175" @default.
- NCIT_C95710 NCIT_P210 "1469876-18-3" @default.
- NCIT_C95710 NCIT_P319 "8E3HI6QQ9J" @default.
- NCIT_C95710 NCIT_P322 "CTRP" @default.
- NCIT_C95710 NCIT_P322 "FDA" @default.
- NCIT_C95710 NCIT_P322 "GDC" @default.
- NCIT_C95710 NCIT_P329 "692828" @default.
- NCIT_C95710 NCIT_P330 "692828" @default.
- NCIT_C95710 NCIT_P375 "Labetuzumab Govitecan" @default.
- NCIT_C95710 NCIT_P399 "692828" @default.
- NCIT_C95710 normalizedInformationContent "100" @default.
- NCIT_C95710 referenceCount "1" @default.
- NCIT_C95710 hasExactSynonym "ADC IMMU-130" @default.
- NCIT_C95710 hasExactSynonym "Antibody-Drug Conjugate IMMU-130" @default.
- NCIT_C95710 hasExactSynonym "LABETUZUMAB GOVITECAN" @default.
- NCIT_C95710 hasExactSynonym "Labetuzumab Govitecan" @default.
- NCIT_C95710 hasExactSynonym "Labetuzumab-SN-38 Immunoconjugate IMMU-130" @default.
- NCIT_C95710 hasExactSynonym "hMN14-SN38" @default.
- NCIT_C95710 inSubset NCIT_C116977 @default.
- NCIT_C95710 inSubset NCIT_C116978 @default.
- NCIT_C95710 inSubset NCIT_C128784 @default.
- NCIT_C95710 inSubset NCIT_C157711 @default.
- NCIT_C95710 inSubset NCIT_C157712 @default.
- NCIT_C95710 inSubset NCIT_C176424 @default.
- NCIT_C95710 inSubset NCIT_C177537 @default.
- NCIT_C95710 inSubset NCIT_C63923 @default.
- NCIT_C95710 type Class @default.
- NCIT_C95710 isDefinedBy ncit.owl @default.
- NCIT_C95710 label "Labetuzumab Govitecan" @default.
- NCIT_C95710 subClassOf NCIT_C129821 @default.
- NCIT_C95710 subClassOf NCIT_C129823 @default.
- NCIT_C95710 subClassOf NCIT_C1512 @default.
- NCIT_C95710 subClassOf NCIT_C163758 @default.
- NCIT_C95710 subClassOf NCIT_C1908 @default.
- NCIT_C95710 subClassOf NCIT_C1909 @default.
- NCIT_C95710 subClassOf NCIT_C200043 @default.
- NCIT_C95710 subClassOf NCIT_C201549 @default.
- NCIT_C95710 subClassOf NCIT_C274 @default.
- NCIT_C95710 subClassOf NCIT_C307 @default.
- NCIT_C95710 subClassOf NCIT_C308 @default.
- NCIT_C95710 subClassOf NCIT_C95710 @default.