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- NCIT_C95711 IAO_0000115 "A radioconjugate containing the purine scaffold heat shock protein 90 (Hsp90) inhibitor PUH71 labeled with the radioisotope iodine I 124, with positron emitting activity. Hsp90 inhibitor PUH71 is thought to bind to cytosolic Hsp90 and the endoplasmic reticulum paralogue gp96 (HSP90B1), thereby inhibiting its molecular chaperone function and promoting the degradation of the oncogenic signaling proteins. This induces caspase-dependent apoptosis. The iodine I 124 moiety can be visualized using Positron emission tomography (PET) imaging, thereby allowing an assessment of the accumulation of PUH71 in vivo, particularly in tumors. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins." @default.
- NCIT_C95711 NCIT_A7 NCIT_C17766 @default.
- NCIT_C95711 NCIT_NHC0 "C95711" @default.
- NCIT_C95711 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C95711 NCIT_P107 "Iodine I 124-labeled Hsp90 Inhibitor PUH71" @default.
- NCIT_C95711 NCIT_P108 "Iodine I 124-labeled Hsp90 Inhibitor PUH71" @default.
- NCIT_C95711 NCIT_P171 "20977755" @default.
- NCIT_C95711 NCIT_P207 "C2987351" @default.
- NCIT_C95711 NCIT_P322 "CTRP" @default.
- NCIT_C95711 NCIT_P329 "692725" @default.
- NCIT_C95711 NCIT_P330 "692725" @default.
- NCIT_C95711 NCIT_P399 "692725" @default.
- NCIT_C95711 normalizedInformationContent "100" @default.
- NCIT_C95711 referenceCount "1" @default.
- NCIT_C95711 hasExactSynonym "124I-PUH71" @default.
- NCIT_C95711 hasExactSynonym "Iodine I 124 PUH71" @default.
- NCIT_C95711 hasExactSynonym "Iodine I 124-labeled Hsp90 Inhibitor PUH71" @default.
- NCIT_C95711 inSubset NCIT_C116977 @default.
- NCIT_C95711 inSubset NCIT_C116978 @default.
- NCIT_C95711 inSubset NCIT_C176424 @default.
- NCIT_C95711 type Class @default.
- NCIT_C95711 isDefinedBy ncit.owl @default.
- NCIT_C95711 label "Iodine I 124-labeled Hsp90 Inhibitor PUH71" @default.
- NCIT_C95711 subClassOf NCIT_C1446 @default.
- NCIT_C95711 subClassOf NCIT_C1908 @default.
- NCIT_C95711 subClassOf NCIT_C1909 @default.
- NCIT_C95711 subClassOf NCIT_C2124 @default.
- NCIT_C95711 subClassOf NCIT_C95711 @default.