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- NCIT_C95718 IAO_0000115 "The liposomal formulation of a c-raf-1 antisense oligonucleotide, with potential antineoplastic activity. Liposomal c-raf antisense oligonucleotide targets the translation initiation site of human c-raf-1 mRNA, thereby blocking the expression and production of Raf-1 protein and thus inhibit tumor cell growth and development. Raf-1 plays a key role in the RAF/MEK/ERK signaling pathway, which regulates mammalian cell proliferation and growth. The liposomal formulation increases the solubility of the c-raf antisense oligonucleotide, thus improving its pharmacodynamic profile." @default.
- NCIT_C95718 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95718 NCIT_NHC0 "C95718" @default.
- NCIT_C95718 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C95718 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95718 NCIT_P108 "Liposomal c-raf Antisense Oligonucleotide" @default.
- NCIT_C95718 NCIT_P207 "C1436330" @default.
- NCIT_C95718 NCIT_P322 "GDC" @default.
- NCIT_C95718 NCIT_P329 "419645" @default.
- NCIT_C95718 NCIT_P330 "419645" @default.
- NCIT_C95718 NCIT_P375 "Liposomal c-raf Antisense Oligonucleotide" @default.
- NCIT_C95718 NCIT_P399 "419645" @default.
- NCIT_C95718 normalizedInformationContent "100" @default.
- NCIT_C95718 referenceCount "1" @default.
- NCIT_C95718 hasExactSynonym "LErafAON" @default.
- NCIT_C95718 hasExactSynonym "Liposomal c-raf Antisense Oligonucleotide" @default.
- NCIT_C95718 hasExactSynonym "c-raf Antisense Oligodeoxynucleotide Liposome" @default.
- NCIT_C95718 hasExactSynonym "liposome-encapsulated c-raf Antisense Oligodeoxynucleotide" @default.
- NCIT_C95718 inSubset NCIT_C128784 @default.
- NCIT_C95718 inSubset NCIT_C157711 @default.
- NCIT_C95718 inSubset NCIT_C157712 @default.
- NCIT_C95718 inSubset NCIT_C176424 @default.
- NCIT_C95718 inSubset NCIT_C177537 @default.
- NCIT_C95718 type Class @default.
- NCIT_C95718 isDefinedBy ncit.owl @default.
- NCIT_C95718 label "Liposomal c-raf Antisense Oligonucleotide" @default.
- NCIT_C95718 subClassOf NCIT_C1291 @default.
- NCIT_C95718 subClassOf NCIT_C129824 @default.
- NCIT_C95718 subClassOf NCIT_C129825 @default.
- NCIT_C95718 subClassOf NCIT_C1908 @default.
- NCIT_C95718 subClassOf NCIT_C1909 @default.
- NCIT_C95718 subClassOf NCIT_C1962 @default.
- NCIT_C95718 subClassOf NCIT_C2189 @default.
- NCIT_C95718 subClassOf NCIT_C274 @default.
- NCIT_C95718 subClassOf NCIT_C307 @default.
- NCIT_C95718 subClassOf NCIT_C471 @default.
- NCIT_C95718 subClassOf NCIT_C95718 @default.