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- NCIT_C95719 IAO_0000115 "A monoclonal antibody directed against the Notch receptor with potential antineoplastic activity. Tarextumab binds to Notch on the cell surface, thereby inhibiting Notch-mediated signaling and gene transcription, which may impede tumor angiogenesis. Notch receptors are important for cell-cell communication, which involves gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. Dysregulated Notch signaling is implicated in many diseases including T-ALL (T-cell acute lymphoblastic leukemia), CADASIL (Cerebral Autosomal Dominant Arteriopathy with Sub-cortical Infarcts and Leukoencephalopathy), MS (Multiple Sclerosis), and many other disease states." @default.
- NCIT_C95719 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95719 NCIT_A7 NCIT_C106438 @default.
- NCIT_C95719 NCIT_A7 NCIT_C97679 @default.
- NCIT_C95719 NCIT_NHC0 "C95719" @default.
- NCIT_C95719 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C95719 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95719 NCIT_P107 "Tarextumab" @default.
- NCIT_C95719 NCIT_P108 "Tarextumab" @default.
- NCIT_C95719 NCIT_P207 "C4053948" @default.
- NCIT_C95719 NCIT_P210 "1359940-55-8" @default.
- NCIT_C95719 NCIT_P319 "333YMY788E" @default.
- NCIT_C95719 NCIT_P322 "CTRP" @default.
- NCIT_C95719 NCIT_P322 "FDA" @default.
- NCIT_C95719 NCIT_P322 "GDC" @default.
- NCIT_C95719 NCIT_P329 "693946" @default.
- NCIT_C95719 NCIT_P330 "693946" @default.
- NCIT_C95719 NCIT_P375 "Tarextumab" @default.
- NCIT_C95719 NCIT_P399 "693946" @default.
- NCIT_C95719 NCIT_R124 NCIT_C17710 @default.
- NCIT_C95719 NCIT_R124 NCIT_C17828 @default.
- NCIT_C95719 NCIT_R124 NCIT_C18219 @default.
- NCIT_C95719 NCIT_R124 NCIT_C19986 @default.
- NCIT_C95719 NCIT_R124 NCIT_C40474 @default.
- NCIT_C95719 normalizedInformationContent "100" @default.
- NCIT_C95719 referenceCount "1" @default.
- NCIT_C95719 hasExactSynonym "MoAb OMP-59R5" @default.
- NCIT_C95719 hasExactSynonym "OMP 59R5" @default.
- NCIT_C95719 hasExactSynonym "OMP-59R5" @default.
- NCIT_C95719 hasExactSynonym "TAREXTUMAB" @default.
- NCIT_C95719 hasExactSynonym "Tarextumab" @default.
- NCIT_C95719 inSubset NCIT_C116977 @default.
- NCIT_C95719 inSubset NCIT_C116978 @default.
- NCIT_C95719 inSubset NCIT_C128784 @default.
- NCIT_C95719 inSubset NCIT_C157711 @default.
- NCIT_C95719 inSubset NCIT_C157712 @default.
- NCIT_C95719 inSubset NCIT_C176424 @default.
- NCIT_C95719 inSubset NCIT_C177537 @default.
- NCIT_C95719 inSubset NCIT_C63923 @default.
- NCIT_C95719 type Class @default.
- NCIT_C95719 isDefinedBy ncit.owl @default.
- NCIT_C95719 label "Tarextumab" @default.
- NCIT_C95719 subClassOf NCIT_C129821 @default.
- NCIT_C95719 subClassOf NCIT_C129822 @default.
- NCIT_C95719 subClassOf NCIT_C1908 @default.
- NCIT_C95719 subClassOf NCIT_C1909 @default.
- NCIT_C95719 subClassOf NCIT_C20401 @default.
- NCIT_C95719 subClassOf NCIT_C274 @default.
- NCIT_C95719 subClassOf NCIT_C307 @default.
- NCIT_C95719 subClassOf NCIT_C308 @default.
- NCIT_C95719 subClassOf NCIT_C95719 @default.