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- NCIT_C95723 IAO_0000115 "An orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor ZSTK474 inhibits all four PI3K isoforms. Inhibiting the activation of the PI3K/AKT kinase (or protein kinase B) signaling pathway results in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. This agent does not induce apoptosis but rather induces strong G(0)/G(1) arrest, which might contribute to its favorable efficacy in tumor cells." @default.
- NCIT_C95723 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95723 NCIT_A7 NCIT_C17270 @default.
- NCIT_C95723 NCIT_NHC0 "C95723" @default.
- NCIT_C95723 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95723 NCIT_P107 "PI3K Inhibitor ZSTK474" @default.
- NCIT_C95723 NCIT_P108 "PI3K Inhibitor ZSTK474" @default.
- NCIT_C95723 NCIT_P207 "C1721602" @default.
- NCIT_C95723 NCIT_P210 "475110-96-4" @default.
- NCIT_C95723 NCIT_P319 "K0068GK39A" @default.
- NCIT_C95723 NCIT_P322 "CTRP" @default.
- NCIT_C95723 NCIT_P322 "FDA" @default.
- NCIT_C95723 NCIT_P322 "GDC" @default.
- NCIT_C95723 NCIT_P329 "694436" @default.
- NCIT_C95723 NCIT_P330 "694436" @default.
- NCIT_C95723 NCIT_P375 "PI3K Inhibitor ZSTK474" @default.
- NCIT_C95723 NCIT_P399 "694436" @default.
- NCIT_C95723 normalizedInformationContent "100" @default.
- NCIT_C95723 referenceCount "1" @default.
- NCIT_C95723 hasExactSynonym "PI3K Inhibitor ZSTK474" @default.
- NCIT_C95723 hasExactSynonym "Phosphatidylinositol 3-kinase Inhibitor ZSTK474" @default.
- NCIT_C95723 hasExactSynonym "ZSTK-474" @default.
- NCIT_C95723 hasExactSynonym "ZSTK474" @default.
- NCIT_C95723 inSubset NCIT_C116977 @default.
- NCIT_C95723 inSubset NCIT_C116978 @default.
- NCIT_C95723 inSubset NCIT_C128784 @default.
- NCIT_C95723 inSubset NCIT_C157711 @default.
- NCIT_C95723 inSubset NCIT_C157712 @default.
- NCIT_C95723 inSubset NCIT_C176424 @default.
- NCIT_C95723 inSubset NCIT_C177537 @default.
- NCIT_C95723 inSubset NCIT_C63923 @default.
- NCIT_C95723 type Class @default.
- NCIT_C95723 isDefinedBy ncit.owl @default.
- NCIT_C95723 label "PI3K Inhibitor ZSTK474" @default.
- NCIT_C95723 subClassOf NCIT_C129824 @default.
- NCIT_C95723 subClassOf NCIT_C129825 @default.
- NCIT_C95723 subClassOf NCIT_C1404 @default.
- NCIT_C95723 subClassOf NCIT_C163758 @default.
- NCIT_C95723 subClassOf NCIT_C1742 @default.
- NCIT_C95723 subClassOf NCIT_C1908 @default.
- NCIT_C95723 subClassOf NCIT_C1909 @default.
- NCIT_C95723 subClassOf NCIT_C2152 @default.
- NCIT_C95723 subClassOf NCIT_C2189 @default.
- NCIT_C95723 subClassOf NCIT_C274 @default.
- NCIT_C95723 subClassOf NCIT_C471 @default.
- NCIT_C95723 subClassOf NCIT_C95723 @default.