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- NCIT_C95727 IAO_0000115 "A recombinant plasmid DNA vaccine containing mammalian expression vector, pUMVC3, encoding epitopes of human Insulin-Like Growth Factor-Binding Protein 2 (hIGFBP-2) with potential antineoplastic activity. Upon vaccination, pUMVC3-hIGFBP-2 multi-epitope plasmid DNA vaccine may produce IGFBP-2 that binds to cell surface, likely via integrin complexes. This results in the dephosphorylation of the focal adhesion-kinase (FAK) and of the p42/44 MAP-kinases, thereby inactivating them; both kinases are involved in cell growth regulation. Furthermore, IGFBP-2 promotes de-adhesion of the cells in a dose-dependent manner, hence impeding cell proliferation. The primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism." @default.
- NCIT_C95727 NCIT_A7 NCIT_C17506 @default.
- NCIT_C95727 NCIT_NHC0 "C95727" @default.
- NCIT_C95727 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C95727 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95727 NCIT_P107 "pUMVC3-hIGFBP-2 Multi-epitope Plasmid DNA Vaccine" @default.
- NCIT_C95727 NCIT_P108 "pUMVC3-hIGFBP-2 Multi-epitope Plasmid DNA Vaccine" @default.
- NCIT_C95727 NCIT_P208 "CL428188" @default.
- NCIT_C95727 NCIT_P322 "CTRP" @default.
- NCIT_C95727 NCIT_P329 "694619" @default.
- NCIT_C95727 NCIT_P330 "694619" @default.
- NCIT_C95727 NCIT_P399 "694619" @default.
- NCIT_C95727 normalizedInformationContent "100" @default.
- NCIT_C95727 referenceCount "1" @default.
- NCIT_C95727 hasExactSynonym "pUMVC3-hIGFBP-2 Multi-epitope Plasmid DNA Vaccine" @default.
- NCIT_C95727 inSubset NCIT_C116977 @default.
- NCIT_C95727 inSubset NCIT_C116978 @default.
- NCIT_C95727 inSubset NCIT_C128784 @default.
- NCIT_C95727 inSubset NCIT_C176424 @default.
- NCIT_C95727 type Class @default.
- NCIT_C95727 isDefinedBy ncit.owl @default.
- NCIT_C95727 label "pUMVC3-hIGFBP-2 Multi-epitope Plasmid DNA Vaccine" @default.
- NCIT_C95727 subClassOf NCIT_C1908 @default.
- NCIT_C95727 subClassOf NCIT_C1909 @default.
- NCIT_C95727 subClassOf NCIT_C1962 @default.
- NCIT_C95727 subClassOf NCIT_C307 @default.
- NCIT_C95727 subClassOf NCIT_C308 @default.
- NCIT_C95727 subClassOf NCIT_C39619 @default.
- NCIT_C95727 subClassOf NCIT_C923 @default.
- NCIT_C95727 subClassOf NCIT_C95727 @default.