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- NCIT_C95728 IAO_0000115 "A recombinant, proprietary bispecific T-cell engagers (BiTE) antibody directed against human carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic activities. Anti-CEA BiTE monoclonal antibody AMG211 possesses two antigen-recognition sites, one for CEA and one for the CD3 complex, a group of T cell surface glycoproteins that complex with the T cell receptor (TCR). This bispecific monoclonal antibody brings CEA-expressing tumor cells and cytotoxic T lymphocytes (CTLs) and helper T lymphocytes (HTLs) together, which may result in the CTL- and HTL-mediated cell death of CEA-expressing cells. CEA, a tumor associated antigen, is overexpressed in many cancer types, including gastrointestinal, breast, non-small cell lung, and thyroid cancers." @default.
- NCIT_C95728 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95728 NCIT_A7 NCIT_C16384 @default.
- NCIT_C95728 NCIT_NHC0 "C95728" @default.
- NCIT_C95728 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C95728 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95728 NCIT_P107 "Anti-CEA BiTE Monoclonal Antibody AMG211" @default.
- NCIT_C95728 NCIT_P108 "Anti-CEA BiTE Monoclonal Antibody AMG211" @default.
- NCIT_C95728 NCIT_P171 "19342971" @default.
- NCIT_C95728 NCIT_P171 "19953093" @default.
- NCIT_C95728 NCIT_P208 "CL428189" @default.
- NCIT_C95728 NCIT_P322 "CTRP" @default.
- NCIT_C95728 NCIT_P322 "GDC" @default.
- NCIT_C95728 NCIT_P329 "694640" @default.
- NCIT_C95728 NCIT_P330 "694640" @default.
- NCIT_C95728 NCIT_P375 "Anti-CEA BiTE Monoclonal Antibody AMG211" @default.
- NCIT_C95728 NCIT_P399 "694640" @default.
- NCIT_C95728 NCIT_R124 NCIT_C17710 @default.
- NCIT_C95728 NCIT_R124 NCIT_C17828 @default.
- NCIT_C95728 NCIT_R124 NCIT_C18219 @default.
- NCIT_C95728 NCIT_R124 NCIT_C19986 @default.
- NCIT_C95728 NCIT_R124 NCIT_C40474 @default.
- NCIT_C95728 normalizedInformationContent "100" @default.
- NCIT_C95728 referenceCount "1" @default.
- NCIT_C95728 hasExactSynonym "AMG211" @default.
- NCIT_C95728 hasExactSynonym "Anti-CEA BiTE Monoclonal Antibody AMG211" @default.
- NCIT_C95728 hasExactSynonym "MEDI-565" @default.
- NCIT_C95728 hasExactSynonym "MT111" @default.
- NCIT_C95728 inSubset NCIT_C116977 @default.
- NCIT_C95728 inSubset NCIT_C116978 @default.
- NCIT_C95728 inSubset NCIT_C128784 @default.
- NCIT_C95728 inSubset NCIT_C157711 @default.
- NCIT_C95728 inSubset NCIT_C157712 @default.
- NCIT_C95728 inSubset NCIT_C176424 @default.
- NCIT_C95728 inSubset NCIT_C177537 @default.
- NCIT_C95728 type Class @default.
- NCIT_C95728 isDefinedBy ncit.owl @default.
- NCIT_C95728 label "Anti-CEA BiTE Monoclonal Antibody AMG211" @default.
- NCIT_C95728 subClassOf NCIT_C112883 @default.
- NCIT_C95728 subClassOf NCIT_C129821 @default.
- NCIT_C95728 subClassOf NCIT_C129822 @default.
- NCIT_C95728 subClassOf NCIT_C1454 @default.
- NCIT_C95728 subClassOf NCIT_C163758 @default.
- NCIT_C95728 subClassOf NCIT_C1908 @default.
- NCIT_C95728 subClassOf NCIT_C1909 @default.
- NCIT_C95728 subClassOf NCIT_C200043 @default.
- NCIT_C95728 subClassOf NCIT_C201282 @default.
- NCIT_C95728 subClassOf NCIT_C20401 @default.
- NCIT_C95728 subClassOf NCIT_C2456 @default.
- NCIT_C95728 subClassOf NCIT_C274 @default.
- NCIT_C95728 subClassOf NCIT_C28227 @default.
- NCIT_C95728 subClassOf NCIT_C307 @default.
- NCIT_C95728 subClassOf NCIT_C308 @default.
- NCIT_C95728 subClassOf NCIT_C95728 @default.