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- NCIT_C95740 IAO_0000115 "A second-generation antisense oligonucleotide targeting the eukaryotic translation initiation factor 4E (eIF4E) with potential antitumor activity. Antisense oligonucleotide ISIS EIF4ERx suppresses the expression of eIF4E in fast dividing tumor cells. Blocking the expression of eIF4E results in inhibition of the synthesis of tumor angiogenic factors, thereby leading to the inhibition of cellular proliferation and apoptosis in tumor cells. eIF4E is overexpressed in a variety of cancers, is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis and is the rate-limiting component of the eukaryotic translation apparatus." @default.
- NCIT_C95740 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95740 NCIT_A7 NCIT_C105125 @default.
- NCIT_C95740 NCIT_NHC0 "C95740" @default.
- NCIT_C95740 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C95740 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95740 NCIT_P107 "eIF4E Antisense Oligonucleotide ISIS 183750" @default.
- NCIT_C95740 NCIT_P108 "eIF4E Antisense Oligonucleotide ISIS 183750" @default.
- NCIT_C95740 NCIT_P207 "C2987390" @default.
- NCIT_C95740 NCIT_P322 "CTRP" @default.
- NCIT_C95740 NCIT_P322 "GDC" @default.
- NCIT_C95740 NCIT_P329 "680421" @default.
- NCIT_C95740 NCIT_P330 "680421" @default.
- NCIT_C95740 NCIT_P375 "eIF4E Antisense Oligonucleotide ISIS 183750" @default.
- NCIT_C95740 NCIT_P399 "680421" @default.
- NCIT_C95740 normalizedInformationContent "100" @default.
- NCIT_C95740 referenceCount "1" @default.
- NCIT_C95740 hasExactSynonym "ISIS 183750" @default.
- NCIT_C95740 hasExactSynonym "LY2275796" @default.
- NCIT_C95740 hasExactSynonym "eIF4E Antisense Oligonucleotide ISIS 183750" @default.
- NCIT_C95740 hasExactSynonym "eIF4E Inhibitor ISIS 183750" @default.
- NCIT_C95740 hasExactSynonym "eIF4E Modulator ISIS 183750" @default.
- NCIT_C95740 inSubset NCIT_C116977 @default.
- NCIT_C95740 inSubset NCIT_C116978 @default.
- NCIT_C95740 inSubset NCIT_C128784 @default.
- NCIT_C95740 inSubset NCIT_C157711 @default.
- NCIT_C95740 inSubset NCIT_C157712 @default.
- NCIT_C95740 inSubset NCIT_C176424 @default.
- NCIT_C95740 inSubset NCIT_C177537 @default.
- NCIT_C95740 type Class @default.
- NCIT_C95740 isDefinedBy ncit.owl @default.
- NCIT_C95740 label "eIF4E Antisense Oligonucleotide ISIS 183750" @default.
- NCIT_C95740 subClassOf NCIT_C1291 @default.
- NCIT_C95740 subClassOf NCIT_C1742 @default.
- NCIT_C95740 subClassOf NCIT_C1908 @default.
- NCIT_C95740 subClassOf NCIT_C1909 @default.
- NCIT_C95740 subClassOf NCIT_C1962 @default.
- NCIT_C95740 subClassOf NCIT_C274 @default.
- NCIT_C95740 subClassOf NCIT_C307 @default.
- NCIT_C95740 subClassOf NCIT_C95740 @default.