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- NCIT_C95742 IAO_0000115 "An optimized, second-generation, PEGylated aptamer with antithrombotic property. Egaptivon pegol blocks the binding of von Willebrand factor (vWF), via the A1 domain, and ultra-large vWF multimers to platelets, as well as interferes with the binding of platelet receptor glycoprotein Ib, thus reducing platelet adhesion, aggregation and thrombus growth in arterial beds. Unlike other antiplatelet agents, this aptamer can be readily reversed by binding to a complementary sequence of oligonucleotides, and may therefore offer potential therapeutic benefit in surgery." @default.
- NCIT_C95742 NCIT_A7 NCIT_C16572 @default.
- NCIT_C95742 NCIT_NHC0 "C95742" @default.
- NCIT_C95742 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95742 NCIT_P107 "Egaptivon Pegol" @default.
- NCIT_C95742 NCIT_P108 "Egaptivon Pegol" @default.
- NCIT_C95742 NCIT_P171 "19479665" @default.
- NCIT_C95742 NCIT_P207 "C2351141" @default.
- NCIT_C95742 NCIT_P210 "934868-74-3" @default.
- NCIT_C95742 NCIT_P319 "DT0445S65M" @default.
- NCIT_C95742 NCIT_P322 "CTRP" @default.
- NCIT_C95742 NCIT_P322 "FDA" @default.
- NCIT_C95742 NCIT_P329 "694584" @default.
- NCIT_C95742 NCIT_P330 "694584" @default.
- NCIT_C95742 NCIT_P399 "694584" @default.
- NCIT_C95742 normalizedInformationContent "100" @default.
- NCIT_C95742 referenceCount "1" @default.
- NCIT_C95742 hasExactSynonym "ARC 1779" @default.
- NCIT_C95742 hasExactSynonym "ARC1779" @default.
- NCIT_C95742 hasExactSynonym "EGAPTIVON PEGOL" @default.
- NCIT_C95742 hasExactSynonym "Egaptivon Pegol" @default.
- NCIT_C95742 inSubset NCIT_C116977 @default.
- NCIT_C95742 inSubset NCIT_C116978 @default.
- NCIT_C95742 inSubset NCIT_C176424 @default.
- NCIT_C95742 inSubset NCIT_C63923 @default.
- NCIT_C95742 type Class @default.
- NCIT_C95742 isDefinedBy ncit.owl @default.
- NCIT_C95742 label "Egaptivon Pegol" @default.
- NCIT_C95742 subClassOf NCIT_C1327 @default.
- NCIT_C95742 subClassOf NCIT_C1908 @default.
- NCIT_C95742 subClassOf NCIT_C1909 @default.
- NCIT_C95742 subClassOf NCIT_C78275 @default.
- NCIT_C95742 subClassOf NCIT_C95742 @default.