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- NCIT_C95764 IAO_0000115 "An immunoconjugate consisting of a humanized monoclonal antibody against the tumor-associated sialoglycotope CA6 (huDS6) conjugated to the cytotoxic maytansinoid DM4, with potential antineoplastic activity. The anti-CA6 monoclonal antibody moiety of SAR566658 targets and binds to the cell surface antigen CA6. Upon antibody/antigen binding and internalization, the immunoconjugate releases DM4, which binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting in inhibition of cell division and cell growth of CA6-expressing tumor cells. The CA6 epitope is found on a variety of solid tumors, including breast, ovarian, cervical, lung and pancreatic tumors." @default.
- NCIT_C95764 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95764 NCIT_NHC0 "C95764" @default.
- NCIT_C95764 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95764 NCIT_P108 "Anti-CA6-DM4 Immunoconjugate SAR566658" @default.
- NCIT_C95764 NCIT_P208 "CL421654" @default.
- NCIT_C95764 NCIT_P319 "UFB8CT84JS" @default.
- NCIT_C95764 NCIT_P322 "FDA" @default.
- NCIT_C95764 NCIT_P322 "GDC" @default.
- NCIT_C95764 NCIT_P329 "681584" @default.
- NCIT_C95764 NCIT_P330 "681584" @default.
- NCIT_C95764 NCIT_P375 "Anti-CA6-DM4 Immunoconjugate SAR566658" @default.
- NCIT_C95764 NCIT_P399 "681584" @default.
- NCIT_C95764 normalizedInformationContent "100" @default.
- NCIT_C95764 referenceCount "1" @default.
- NCIT_C95764 hasExactSynonym "Anti-CA6-DM4 Immunoconjugate SAR566658" @default.
- NCIT_C95764 hasExactSynonym "SAR-566658" @default.
- NCIT_C95764 hasExactSynonym "SAR566658" @default.
- NCIT_C95764 hasExactSynonym "huDs6-DM4" @default.
- NCIT_C95764 inSubset NCIT_C128784 @default.
- NCIT_C95764 inSubset NCIT_C157711 @default.
- NCIT_C95764 inSubset NCIT_C157712 @default.
- NCIT_C95764 inSubset NCIT_C176424 @default.
- NCIT_C95764 inSubset NCIT_C177537 @default.
- NCIT_C95764 inSubset NCIT_C63923 @default.
- NCIT_C95764 type Class @default.
- NCIT_C95764 isDefinedBy ncit.owl @default.
- NCIT_C95764 label "Anti-CA6-DM4 Immunoconjugate SAR566658" @default.
- NCIT_C95764 subClassOf NCIT_C1512 @default.
- NCIT_C95764 subClassOf NCIT_C1908 @default.
- NCIT_C95764 subClassOf NCIT_C1909 @default.
- NCIT_C95764 subClassOf NCIT_C307 @default.
- NCIT_C95764 subClassOf NCIT_C308 @default.
- NCIT_C95764 subClassOf NCIT_C575 @default.
- NCIT_C95764 subClassOf NCIT_C95764 @default.