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- NCIT_C95769 IAO_0000115 "An orally available crystalline formulation of genistein, a soy-derived isoflavone and phytoestrogen with potential antineoplastic, chemosensitizing, and antioxidant activities. Similar to genistein, crystalline genistein formulation AXP107-11 increases expression of phosphatase and tensin homolog (PTEN), which deactivates protein kinase Akt and mitogen-activated protein kinases (MAPK1 and 3; ERK2 and 1), thereby disrupting PI3K/Akt signal transduction and inducing apoptosis. This agent also induces antioxidant enzymes through AMP-activated protein kinase (AMPK) activation, inhibits NF-kB activation and decreases inflammation response, thereby sensitizing tumors to chemotherapy. Compared to genistein itself, this crystalline formulation shows improved solubility and bioavailability." @default.
- NCIT_C95769 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95769 NCIT_NHC0 "C95769" @default.
- NCIT_C95769 NCIT_P106 "Organic Chemical" @default.
- NCIT_C95769 NCIT_P108 "Crystalline Genistein Formulation AXP107-11" @default.
- NCIT_C95769 NCIT_P208 "CL428211" @default.
- NCIT_C95769 NCIT_P322 "GDC" @default.
- NCIT_C95769 NCIT_P329 "683963" @default.
- NCIT_C95769 NCIT_P330 "683963" @default.
- NCIT_C95769 NCIT_P375 "Crystalline Genistein Formulation AXP107-11" @default.
- NCIT_C95769 NCIT_P399 "683963" @default.
- NCIT_C95769 normalizedInformationContent "100" @default.
- NCIT_C95769 referenceCount "1" @default.
- NCIT_C95769 hasExactSynonym "AXP107-11" @default.
- NCIT_C95769 hasExactSynonym "Crystalline Genistein Formulation AXP107-11" @default.
- NCIT_C95769 inSubset NCIT_C128784 @default.
- NCIT_C95769 inSubset NCIT_C157711 @default.
- NCIT_C95769 inSubset NCIT_C157712 @default.
- NCIT_C95769 inSubset NCIT_C176424 @default.
- NCIT_C95769 inSubset NCIT_C177537 @default.
- NCIT_C95769 type Class @default.
- NCIT_C95769 isDefinedBy ncit.owl @default.
- NCIT_C95769 label "Crystalline Genistein Formulation AXP107-11" @default.
- NCIT_C95769 subClassOf NCIT_C1908 @default.
- NCIT_C95769 subClassOf NCIT_C1913 @default.
- NCIT_C95769 subClassOf NCIT_C1915 @default.
- NCIT_C95769 subClassOf NCIT_C1930 @default.
- NCIT_C95769 subClassOf NCIT_C1933 @default.
- NCIT_C95769 subClassOf NCIT_C1949 @default.
- NCIT_C95769 subClassOf NCIT_C28203 @default.
- NCIT_C95769 subClassOf NCIT_C54060 @default.
- NCIT_C95769 subClassOf NCIT_C552 @default.
- NCIT_C95769 subClassOf NCIT_C553 @default.
- NCIT_C95769 subClassOf NCIT_C599 @default.
- NCIT_C95769 subClassOf NCIT_C68464 @default.
- NCIT_C95769 subClassOf NCIT_C70553 @default.
- NCIT_C95769 subClassOf NCIT_C70554 @default.
- NCIT_C95769 subClassOf NCIT_C718 @default.
- NCIT_C95769 subClassOf NCIT_C95769 @default.