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- NCIT_C95777 IAO_0000115 "An orally bioavailable multitargeted receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities. Ponatinib inhibits unmutated and all mutated forms of Bcr-Abl, including T315I, the highly drug therapy-resistant missense mutation of Bcr-Abl. This agent also inhibits other tyrosine kinases including those associated with vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs); in addition, it inhibits the tyrosine kinase receptor TIE2 and FMS-related tyrosine kinase receptor-3 (Flt3). RTK inhibition by ponatinib may result in the inhibition of cellular proliferation and angiogenesis and may induce cell death. Bcr-Abl is a fusion tyrosine kinase encoded by the Philadelphia chromosome." @default.
- NCIT_C95777 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95777 NCIT_A5 NCIT_C78194 @default.
- NCIT_C95777 NCIT_A7 NCIT_C18488 @default.
- NCIT_C95777 NCIT_NHC0 "C95777" @default.
- NCIT_C95777 NCIT_P106 "Organic Chemical" @default.
- NCIT_C95777 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95777 NCIT_P108 "Ponatinib" @default.
- NCIT_C95777 NCIT_P207 "C2987417" @default.
- NCIT_C95777 NCIT_P210 "943319-70-8" @default.
- NCIT_C95777 NCIT_P319 "4340891KFS" @default.
- NCIT_C95777 NCIT_P322 "FDA" @default.
- NCIT_C95777 NCIT_P322 "GDC" @default.
- NCIT_C95777 NCIT_P350 "C29H27F3N6O" @default.
- NCIT_C95777 NCIT_P375 "Ponatinib" @default.
- NCIT_C95777 NCIT_R124 NCIT_C17828 @default.
- NCIT_C95777 NCIT_R124 NCIT_C18992 @default.
- NCIT_C95777 NCIT_R124 NCIT_C19143 @default.
- NCIT_C95777 NCIT_R124 NCIT_C21124 @default.
- NCIT_C95777 NCIT_R124 NCIT_C40702 @default.
- NCIT_C95777 NCIT_R124 NCIT_C40703 @default.
- NCIT_C95777 NCIT_R124 NCIT_C40704 @default.
- NCIT_C95777 NCIT_R125 NCIT_C17133 @default.
- NCIT_C95777 NCIT_R125 NCIT_C17828 @default.
- NCIT_C95777 NCIT_R125 NCIT_C18081 @default.
- NCIT_C95777 NCIT_R125 NCIT_C20480 @default.
- NCIT_C95777 NCIT_R125 NCIT_C20751 @default.
- NCIT_C95777 NCIT_R125 NCIT_C40821 @default.
- NCIT_C95777 normalizedInformationContent "100" @default.
- NCIT_C95777 referenceCount "1" @default.
- NCIT_C95777 hasExactSynonym "AP-24534" @default.
- NCIT_C95777 hasExactSynonym "AP24534" @default.
- NCIT_C95777 hasExactSynonym "Benzamide, 3-(2-Imidazo(1,2-B)Pyridazin-3-Ylethynyl)-4-Methyl-N-(4-((4-Methyl-1- Piperazinyl)Methyl)-3-(Trifluoromethyl)Phenyl)" @default.
- NCIT_C95777 hasExactSynonym "PONATINIB" @default.
- NCIT_C95777 hasExactSynonym "Ponatinib" @default.
- NCIT_C95777 inSubset NCIT_C128784 @default.
- NCIT_C95777 inSubset NCIT_C157711 @default.
- NCIT_C95777 inSubset NCIT_C157712 @default.
- NCIT_C95777 inSubset NCIT_C177537 @default.
- NCIT_C95777 inSubset NCIT_C63923 @default.
- NCIT_C95777 type Class @default.
- NCIT_C95777 isDefinedBy ncit.owl @default.
- NCIT_C95777 label "Ponatinib" @default.
- NCIT_C95777 subClassOf NCIT_C124800 @default.
- NCIT_C95777 subClassOf NCIT_C129824 @default.
- NCIT_C95777 subClassOf NCIT_C129825 @default.
- NCIT_C95777 subClassOf NCIT_C1404 @default.
- NCIT_C95777 subClassOf NCIT_C155700 @default.
- NCIT_C95777 subClassOf NCIT_C155727 @default.
- NCIT_C95777 subClassOf NCIT_C159198 @default.
- NCIT_C95777 subClassOf NCIT_C159199 @default.
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- NCIT_C95777 subClassOf NCIT_C163758 @default.
- NCIT_C95777 subClassOf NCIT_C163790 @default.
- NCIT_C95777 subClassOf NCIT_C163953 @default.
- NCIT_C95777 subClassOf NCIT_C163999 @default.
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- NCIT_C95777 subClassOf NCIT_C1908 @default.
- NCIT_C95777 subClassOf NCIT_C1909 @default.
- NCIT_C95777 subClassOf NCIT_C1967 @default.
- NCIT_C95777 subClassOf NCIT_C2189 @default.
- NCIT_C95777 subClassOf NCIT_C274 @default.
- NCIT_C95777 subClassOf NCIT_C471 @default.
- NCIT_C95777 subClassOf NCIT_C93259 @default.
- NCIT_C95777 subClassOf NCIT_C95777 @default.