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- NCIT_C95797 IAO_0000115 "A recombinant, fully human monoclonal antibody directed against the insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic activity. Teprotumumab binds to membrane-bound IGF-1R, preventing the binding of the natural ligand IGF-1 and the activation of PI3K/AKT signal transduction; downregulation of the PI3K/AKT survival pathway may result in the induction of apoptosis and decreased cellular proliferation. The activation of IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been implicated in tumorigenesis and metastasis." @default.
- NCIT_C95797 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95797 NCIT_A7 NCIT_C17531 @default.
- NCIT_C95797 NCIT_NHC0 "C95797" @default.
- NCIT_C95797 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C95797 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C95797 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95797 NCIT_P107 "Teprotumumab" @default.
- NCIT_C95797 NCIT_P108 "Teprotumumab" @default.
- NCIT_C95797 NCIT_P207 "C3181764" @default.
- NCIT_C95797 NCIT_P210 "89957-37-9" @default.
- NCIT_C95797 NCIT_P302 "Treatment of solid and hematologic tumors" @default.
- NCIT_C95797 NCIT_P319 "Y64GQ0KC0A" @default.
- NCIT_C95797 NCIT_P322 "CTRP" @default.
- NCIT_C95797 NCIT_P322 "FDA" @default.
- NCIT_C95797 NCIT_P322 "GDC" @default.
- NCIT_C95797 NCIT_P325 "A human monoclonal antibody being studied in the treatment of several types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. R1507 blocks the action of a protein needed for cell growth and may kill cancer cells. It is a type of insulin-like growth factor-1 receptor (IGF-1R) inhibitor." @default.
- NCIT_C95797 NCIT_P329 "557569" @default.
- NCIT_C95797 NCIT_P330 "557569" @default.
- NCIT_C95797 NCIT_P375 "Teprotumumab" @default.
- NCIT_C95797 NCIT_P399 "557569" @default.
- NCIT_C95797 NCIT_R124 NCIT_C17710 @default.
- NCIT_C95797 NCIT_R124 NCIT_C17828 @default.
- NCIT_C95797 NCIT_R124 NCIT_C18219 @default.
- NCIT_C95797 NCIT_R124 NCIT_C19986 @default.
- NCIT_C95797 NCIT_R124 NCIT_C40474 @default.
- NCIT_C95797 normalizedInformationContent "100" @default.
- NCIT_C95797 referenceCount "1" @default.
- NCIT_C95797 hasExactSynonym "Anti-IGF-1R Monoclonal Antibody R1507" @default.
- NCIT_C95797 hasExactSynonym "Immunoglobulin G1, Anti-(Human Insulin-like Growth Factor I Receptor)(Human Monoclonal Heavy Chain), Disulfide with Human Monoclonal Light Chain, Dimer" @default.
- NCIT_C95797 hasExactSynonym "R1507" @default.
- NCIT_C95797 hasExactSynonym "RG1507" @default.
- NCIT_C95797 hasExactSynonym "RO4858696-000" @default.
- NCIT_C95797 hasExactSynonym "RV001 Monoclonal" @default.
- NCIT_C95797 hasExactSynonym "TEPROTUMUMAB" @default.
- NCIT_C95797 hasExactSynonym "Teprotumumab" @default.
- NCIT_C95797 inSubset NCIT_C116977 @default.
- NCIT_C95797 inSubset NCIT_C116978 @default.
- NCIT_C95797 inSubset NCIT_C128784 @default.
- NCIT_C95797 inSubset NCIT_C157711 @default.
- NCIT_C95797 inSubset NCIT_C157712 @default.
- NCIT_C95797 inSubset NCIT_C176424 @default.
- NCIT_C95797 inSubset NCIT_C177537 @default.
- NCIT_C95797 inSubset NCIT_C63923 @default.
- NCIT_C95797 type Class @default.
- NCIT_C95797 isDefinedBy ncit.owl @default.
- NCIT_C95797 label "Teprotumumab" @default.
- NCIT_C95797 subClassOf NCIT_C129821 @default.
- NCIT_C95797 subClassOf NCIT_C129822 @default.
- NCIT_C95797 subClassOf NCIT_C1742 @default.
- NCIT_C95797 subClassOf NCIT_C182012 @default.
- NCIT_C95797 subClassOf NCIT_C1908 @default.
- NCIT_C95797 subClassOf NCIT_C1909 @default.
- NCIT_C95797 subClassOf NCIT_C20401 @default.
- NCIT_C95797 subClassOf NCIT_C274 @default.
- NCIT_C95797 subClassOf NCIT_C307 @default.
- NCIT_C95797 subClassOf NCIT_C308 @default.
- NCIT_C95797 subClassOf NCIT_C95797 @default.