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- NCIT_C95798 IAO_0000115 "A recombinant humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the human lymphocyte Peyer's patch adhesion molecule 1 (LPAM-1; alpha4beta7; a4b7), with immunomodulating, anti-inflammatory, and potential antineoplastic activities. Upon administration, vedolizumab selectively binds to integrin a4b7 and prevents the binding of a4b7, expressed on the surface of a subset of T-lymphocytes, to its natural ligand, mucosal addressin cell adhesion molecule-1 (MAdCAM-1), which is mainly expressed on the surface of gut endothelial cells. This prevents a4b7-mediated signaling, adhesion of lymphocytes to the endothelium and the migration of T-lymphocytes across the endothelium into inflamed gastrointestinal (GI) tissue. By preventing this infiltration to the affected area, inflammation is reduced. The human lymphocyte a4b7 integrin, plays a key role in gastrointestinal (GI) inflammation; it is overexpressed in certain types of cancer cells. The alpha4beta7/MAdCAM-1 signaling pathway plays a critical role in the homing of T-lymphocytes to intestinal tissue." @default.
- NCIT_C95798 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95798 NCIT_A7 NCIT_C121993 @default.
- NCIT_C95798 NCIT_NHC0 "C95798" @default.
- NCIT_C95798 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C95798 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C95798 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95798 NCIT_P107 "Vedolizumab" @default.
- NCIT_C95798 NCIT_P108 "Vedolizumab" @default.
- NCIT_C95798 NCIT_P207 "C2742797" @default.
- NCIT_C95798 NCIT_P210 "943609-66-3" @default.
- NCIT_C95798 NCIT_P302 "Treatment of ulcerative colitis and Crohn's disease" @default.
- NCIT_C95798 NCIT_P319 "9RV78Q2002" @default.
- NCIT_C95798 NCIT_P322 "CTRP" @default.
- NCIT_C95798 NCIT_P322 "FDA" @default.
- NCIT_C95798 NCIT_P322 "GDC" @default.
- NCIT_C95798 NCIT_P329 "781604" @default.
- NCIT_C95798 NCIT_P330 "781604" @default.
- NCIT_C95798 NCIT_P375 "Vedolizumab" @default.
- NCIT_C95798 NCIT_P399 "781604" @default.
- NCIT_C95798 NCIT_R124 NCIT_C17710 @default.
- NCIT_C95798 NCIT_R124 NCIT_C17828 @default.
- NCIT_C95798 NCIT_R124 NCIT_C18219 @default.
- NCIT_C95798 NCIT_R124 NCIT_C19986 @default.
- NCIT_C95798 NCIT_R124 NCIT_C40474 @default.
- NCIT_C95798 normalizedInformationContent "100" @default.
- NCIT_C95798 referenceCount "1" @default.
- NCIT_C95798 hasExactSynonym "Entyvio" @default.
- NCIT_C95798 hasExactSynonym "Immunoglobulin G1, Anti-(Human Integrin LPAM-1 (Lymphocyte Peyer's Patch Adhesion Molecule 1)) (Human-Mus musculus Heavy Chain), Disulfide with Human-Mus musculus kappa-chain, Dimer" @default.
- NCIT_C95798 hasExactSynonym "Immunoglobulin G1, anti-(human integrin LPAM-1 (lymphocyte Peyer's patch adhesion molecule 1)) (human-Mus musculus heavy chain), disulfide with human-Mus musculus kappa-chain, dimer" @default.
- NCIT_C95798 hasExactSynonym "LDP 02" @default.
- NCIT_C95798 hasExactSynonym "LDP-02" @default.
- NCIT_C95798 hasExactSynonym "LDP02" @default.
- NCIT_C95798 hasExactSynonym "MLN0002" @default.
- NCIT_C95798 hasExactSynonym "MLN02" @default.
- NCIT_C95798 hasExactSynonym "VEDOLIZUMAB" @default.
- NCIT_C95798 hasExactSynonym "Vedolizumab" @default.
- NCIT_C95798 inSubset NCIT_C116977 @default.
- NCIT_C95798 inSubset NCIT_C116978 @default.
- NCIT_C95798 inSubset NCIT_C128784 @default.
- NCIT_C95798 inSubset NCIT_C157711 @default.
- NCIT_C95798 inSubset NCIT_C157712 @default.
- NCIT_C95798 inSubset NCIT_C176424 @default.
- NCIT_C95798 inSubset NCIT_C177537 @default.
- NCIT_C95798 inSubset NCIT_C63923 @default.
- NCIT_C95798 type Class @default.
- NCIT_C95798 isDefinedBy ncit.owl @default.
- NCIT_C95798 label "Vedolizumab" @default.
- NCIT_C95798 subClassOf NCIT_C129821 @default.
- NCIT_C95798 subClassOf NCIT_C129822 @default.
- NCIT_C95798 subClassOf NCIT_C1908 @default.
- NCIT_C95798 subClassOf NCIT_C1909 @default.
- NCIT_C95798 subClassOf NCIT_C20401 @default.
- NCIT_C95798 subClassOf NCIT_C274 @default.
- NCIT_C95798 subClassOf NCIT_C307 @default.
- NCIT_C95798 subClassOf NCIT_C308 @default.
- NCIT_C95798 subClassOf NCIT_C95798 @default.