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- NCIT_C958 IAO_0000115 "A polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. (NCI04)" @default.
- NCIT_C958 NCIT_A32 NCIT_C1909 @default.
- NCIT_C958 NCIT_NHC0 "C958" @default.
- NCIT_C958 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C958 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C958 NCIT_P108 "Edatrexate" @default.
- NCIT_C958 NCIT_P175 "626715" @default.
- NCIT_C958 NCIT_P207 "C0044667" @default.
- NCIT_C958 NCIT_P210 "80576-83-6" @default.
- NCIT_C958 NCIT_P319 "JT4X6Z1HRR" @default.
- NCIT_C958 NCIT_P322 "FDA" @default.
- NCIT_C958 NCIT_P322 "GDC" @default.
- NCIT_C958 NCIT_P325 "An anticancer drug that belongs to a family of drugs called antimetabolites." @default.
- NCIT_C958 NCIT_P329 "40887" @default.
- NCIT_C958 NCIT_P330 "40887" @default.
- NCIT_C958 NCIT_P350 "C22H25N7O5" @default.
- NCIT_C958 NCIT_P366 "Edatrexate" @default.
- NCIT_C958 NCIT_P375 "Edatrexate" @default.
- NCIT_C958 NCIT_P399 "40887" @default.
- NCIT_C958 NCIT_R124 NCIT_C17710 @default.
- NCIT_C958 NCIT_R124 NCIT_C17828 @default.
- NCIT_C958 NCIT_R124 NCIT_C28498 @default.
- NCIT_C958 NCIT_R124 NCIT_C40576 @default.
- NCIT_C958 NCIT_R124 NCIT_C40577 @default.
- NCIT_C958 NCIT_R125 NCIT_C17702 @default.
- NCIT_C958 NCIT_R125 NCIT_C17710 @default.
- NCIT_C958 NCIT_R125 NCIT_C17828 @default.
- NCIT_C958 NCIT_R125 NCIT_C19403 @default.
- NCIT_C958 NCIT_R125 NCIT_C19536 @default.
- NCIT_C958 NCIT_R125 NCIT_C20480 @default.
- NCIT_C958 NCIT_R125 NCIT_C21198 @default.
- NCIT_C958 NCIT_R125 NCIT_C28498 @default.
- NCIT_C958 NCIT_R125 NCIT_C30017 @default.
- NCIT_C958 NCIT_R125 NCIT_C40624 @default.
- NCIT_C958 NCIT_R125 NCIT_C40669 @default.
- NCIT_C958 NCIT_R125 NCIT_C40715 @default.
- NCIT_C958 NCIT_R125 NCIT_C41515 @default.
- NCIT_C958 NCIT_R125 NCIT_C41545 @default.
- NCIT_C958 NCIT_R125 NCIT_C41592 @default.
- NCIT_C958 NCIT_R125 NCIT_C51037 @default.
- NCIT_C958 NCIT_R146 NCIT_C16554 @default.
- NCIT_C958 NCIT_R146 NCIT_C16849 @default.
- NCIT_C958 NCIT_R146 NCIT_C16946 @default.
- NCIT_C958 NCIT_R146 NCIT_C17021 @default.
- NCIT_C958 NCIT_R146 NCIT_C17191 @default.
- NCIT_C958 NCIT_R146 NCIT_C17199 @default.
- NCIT_C958 NCIT_R146 NCIT_C17210 @default.
- NCIT_C958 NCIT_R146 NCIT_C20027 @default.
- NCIT_C958 NCIT_R146 NCIT_C26548 @default.
- NCIT_C958 normalizedInformationContent "83.027314241919257" @default.
- NCIT_C958 referenceCount "13" @default.
- NCIT_C958 hasExactSynonym "10-EDAM" @default.
- NCIT_C958 hasExactSynonym "10-EdAM" @default.
- NCIT_C958 hasExactSynonym "10-Ethyl-10-deaza-aminopterin" @default.
- NCIT_C958 hasExactSynonym "CGP-30694" @default.
- NCIT_C958 hasExactSynonym "EDAM" @default.
- NCIT_C958 hasExactSynonym "EDATREXATE" @default.
- NCIT_C958 hasExactSynonym "Edatrexate" @default.
- NCIT_C958 hasExactSynonym "N-[4-[1-[(2, 4-Diamino-6-pteridinyl)-methyl]propyl]benzoyl]-L-glutamic acid" @default.
- NCIT_C958 hasExactSynonym "N-[4-[1-[(2,4-Diamino-6-pteridinyl)-methyl]propyl]benzoyl]-L-glutamic Acid" @default.
- NCIT_C958 hasExactSynonym "edatrexate" @default.
- NCIT_C958 inSubset NCIT_C128784 @default.
- NCIT_C958 inSubset NCIT_C157711 @default.
- NCIT_C958 inSubset NCIT_C157712 @default.
- NCIT_C958 inSubset NCIT_C176424 @default.
- NCIT_C958 inSubset NCIT_C177537 @default.
- NCIT_C958 inSubset NCIT_C63923 @default.
- NCIT_C958 type Class @default.
- NCIT_C958 isDefinedBy ncit.owl @default.
- NCIT_C958 label "Edatrexate" @default.
- NCIT_C958 subClassOf NCIT_C186664 @default.
- NCIT_C958 subClassOf NCIT_C1908 @default.
- NCIT_C958 subClassOf NCIT_C1909 @default.
- NCIT_C958 subClassOf NCIT_C2153 @default.
- NCIT_C958 subClassOf NCIT_C272 @default.
- NCIT_C958 subClassOf NCIT_C274 @default.
- NCIT_C958 subClassOf NCIT_C471 @default.
- NCIT_C958 subClassOf NCIT_C511 @default.
- NCIT_C958 subClassOf NCIT_C958 @default.
- NCIT_C958 equivalentClass Bca493ce6e695a26b3cfd5d25bf52c4cb @default.
- NCIT_C958 equivalentClass Bea8f6b911523e76bd62f85a482bff39d @default.