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- NCIT_C95800 IAO_0000115 "An orally available inhibitor of Janus kinases (JAK), with immunomodulatory and anti-inflammatory activities. Upon administration, tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers and activators of transcription (STAT) signaling pathway. This may decrease the production of pro-inflammatory cytokines, such as interleukin (IL)-6, -7, -15, -21, interferon-alpha and -beta, and may prevent both an inflammatory response and the inflammation-induced damage caused by certain immunological diseases. JAK kinases are intracellular enzymes involved in signaling pathways affecting hematopoiesis, immunity and inflammation." @default.
- NCIT_C95800 NCIT_A48 NCIT_C17998 @default.
- NCIT_C95800 NCIT_A48 NCIT_C49487 @default.
- NCIT_C95800 NCIT_A48 NCIT_C49488 @default.
- NCIT_C95800 NCIT_A5 NCIT_C95801 @default.
- NCIT_C95800 NCIT_NHC0 "C95800" @default.
- NCIT_C95800 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95800 NCIT_P108 "Tofacitinib" @default.
- NCIT_C95800 NCIT_P207 "C2930696" @default.
- NCIT_C95800 NCIT_P210 "477600-75-2" @default.
- NCIT_C95800 NCIT_P319 "87LA6FU830" @default.
- NCIT_C95800 NCIT_P322 "ACC/AHA" @default.
- NCIT_C95800 NCIT_P322 "FDA" @default.
- NCIT_C95800 NCIT_P329 "759505" @default.
- NCIT_C95800 NCIT_P330 "759505" @default.
- NCIT_C95800 NCIT_P350 "C16H20N6O" @default.
- NCIT_C95800 NCIT_P399 "759505" @default.
- NCIT_C95800 normalizedInformationContent "100" @default.
- NCIT_C95800 referenceCount "1" @default.
- NCIT_C95800 hasExactSynonym "3-((3R,4R)-4-Methyl-3-(Methyl(7H-Pyrrolo(2,3-D)Pyrimidin-4-yl)Amino)Piperidin-1-yl)-3-Oxopropanenitrile" @default.
- NCIT_C95800 hasExactSynonym "CP-690,550 Free Base" @default.
- NCIT_C95800 hasExactSynonym "CP-690550" @default.
- NCIT_C95800 hasExactSynonym "JAK inhibitors: tofacitinib" @default.
- NCIT_C95800 hasExactSynonym "TOFACITINIB" @default.
- NCIT_C95800 hasExactSynonym "Tasocitinib" @default.
- NCIT_C95800 hasExactSynonym "Tofacitinib" @default.
- NCIT_C95800 inSubset NCIT_C173381 @default.
- NCIT_C95800 inSubset NCIT_C173383 @default.
- NCIT_C95800 inSubset NCIT_C176424 @default.
- NCIT_C95800 inSubset NCIT_C191200 @default.
- NCIT_C95800 inSubset NCIT_C191387 @default.
- NCIT_C95800 inSubset NCIT_C191404 @default.
- NCIT_C95800 inSubset NCIT_C191670 @default.
- NCIT_C95800 inSubset NCIT_C63923 @default.
- NCIT_C95800 type Class @default.
- NCIT_C95800 isDefinedBy ncit.owl @default.
- NCIT_C95800 label "Tofacitinib" @default.
- NCIT_C95800 subClassOf NCIT_C129824 @default.
- NCIT_C95800 subClassOf NCIT_C129825 @default.
- NCIT_C95800 subClassOf NCIT_C1404 @default.
- NCIT_C95800 subClassOf NCIT_C172200 @default.
- NCIT_C95800 subClassOf NCIT_C1908 @default.
- NCIT_C95800 subClassOf NCIT_C1909 @default.
- NCIT_C95800 subClassOf NCIT_C1967 @default.
- NCIT_C95800 subClassOf NCIT_C2189 @default.
- NCIT_C95800 subClassOf NCIT_C274 @default.
- NCIT_C95800 subClassOf NCIT_C471 @default.
- NCIT_C95800 subClassOf NCIT_C95800 @default.