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- NCIT_C95889 IAO_0000115 "An orally bioavailable inhibitor of signal transducer and activator of transcription 3 (STAT3), with potential antineoplastic activity. STAT3 inhibitor OPB-51602 inhibits the phosphorylation and thus the activation of STAT3 protein, impeding STAT3 protein from translocating from the cytoplasm to the nucleus and thereby blocking STAT3's regulation of gene expression through direct binding to the promoters of responsive genes. STAT3 regulates the cellular functions that lead to the cancer phenotype, and constitutive activation of STAT3 is observed in a wide range of human cancers, inducing uncontrolled proliferation and neoplastic transformation." @default.
- NCIT_C95889 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95889 NCIT_A7 NCIT_C28664 @default.
- NCIT_C95889 NCIT_NHC0 "C95889" @default.
- NCIT_C95889 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95889 NCIT_P107 "STAT3 Inhibitor OPB-51602" @default.
- NCIT_C95889 NCIT_P108 "STAT3 Inhibitor OPB-51602" @default.
- NCIT_C95889 NCIT_P208 "CL428286" @default.
- NCIT_C95889 NCIT_P322 "CTRP" @default.
- NCIT_C95889 NCIT_P322 "GDC" @default.
- NCIT_C95889 NCIT_P329 "684303" @default.
- NCIT_C95889 NCIT_P330 "684303" @default.
- NCIT_C95889 NCIT_P375 "STAT3 Inhibitor OPB-51602" @default.
- NCIT_C95889 NCIT_P399 "684303" @default.
- NCIT_C95889 normalizedInformationContent "100" @default.
- NCIT_C95889 referenceCount "1" @default.
- NCIT_C95889 hasExactSynonym "OPB-51602" @default.
- NCIT_C95889 hasExactSynonym "STAT3 Inhibitor OPB-51602" @default.
- NCIT_C95889 inSubset NCIT_C116977 @default.
- NCIT_C95889 inSubset NCIT_C116978 @default.
- NCIT_C95889 inSubset NCIT_C128784 @default.
- NCIT_C95889 inSubset NCIT_C157711 @default.
- NCIT_C95889 inSubset NCIT_C157712 @default.
- NCIT_C95889 inSubset NCIT_C176424 @default.
- NCIT_C95889 inSubset NCIT_C177537 @default.
- NCIT_C95889 type Class @default.
- NCIT_C95889 isDefinedBy ncit.owl @default.
- NCIT_C95889 label "STAT3 Inhibitor OPB-51602" @default.
- NCIT_C95889 subClassOf NCIT_C1908 @default.
- NCIT_C95889 subClassOf NCIT_C1909 @default.
- NCIT_C95889 subClassOf NCIT_C2189 @default.
- NCIT_C95889 subClassOf NCIT_C274 @default.
- NCIT_C95889 subClassOf NCIT_C95889 @default.