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- NCIT_C95896 IAO_0000115 "An orally available small molecule dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs) with antiangiogenic and antineoplastic activities. Vorolanib inhibits all isoforms of VEGFR and PDGFR, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and PDGFRs are receptor tyrosine kinases that may be upregulated in various tumor cell types. Vorolanib has been shown to reduce tissue toxicity by 95 percent compared with first-generation kinase inhibitors." @default.
- NCIT_C95896 NCIT_A32 NCIT_C1909 @default.
- NCIT_C95896 NCIT_A7 NCIT_C17293 @default.
- NCIT_C95896 NCIT_A7 NCIT_C17322 @default.
- NCIT_C95896 NCIT_NHC0 "C95896" @default.
- NCIT_C95896 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C95896 NCIT_P107 "Vorolanib" @default.
- NCIT_C95896 NCIT_P108 "Vorolanib" @default.
- NCIT_C95896 NCIT_P208 "CL428293" @default.
- NCIT_C95896 NCIT_P210 "1013920-15-4" @default.
- NCIT_C95896 NCIT_P319 "YP8G3I74EL" @default.
- NCIT_C95896 NCIT_P322 "CTRP" @default.
- NCIT_C95896 NCIT_P322 "FDA" @default.
- NCIT_C95896 NCIT_P322 "GDC" @default.
- NCIT_C95896 NCIT_P329 "695817" @default.
- NCIT_C95896 NCIT_P330 "695817" @default.
- NCIT_C95896 NCIT_P375 "Vorolanib" @default.
- NCIT_C95896 NCIT_P399 "695817" @default.
- NCIT_C95896 normalizedInformationContent "100" @default.
- NCIT_C95896 referenceCount "1" @default.
- NCIT_C95896 hasExactSynonym "(S,Z)-N-(1-(dimethylcarbamoyl)pyrrolidin-3-yl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide" @default.
- NCIT_C95896 hasExactSynonym "CM 082" @default.
- NCIT_C95896 hasExactSynonym "CM-082" @default.
- NCIT_C95896 hasExactSynonym "CM082" @default.
- NCIT_C95896 hasExactSynonym "VOROLANIB" @default.
- NCIT_C95896 hasExactSynonym "Vorolanib" @default.
- NCIT_C95896 hasExactSynonym "X 82" @default.
- NCIT_C95896 hasExactSynonym "X-82" @default.
- NCIT_C95896 inSubset NCIT_C116977 @default.
- NCIT_C95896 inSubset NCIT_C116978 @default.
- NCIT_C95896 inSubset NCIT_C128784 @default.
- NCIT_C95896 inSubset NCIT_C157711 @default.
- NCIT_C95896 inSubset NCIT_C157712 @default.
- NCIT_C95896 inSubset NCIT_C176424 @default.
- NCIT_C95896 inSubset NCIT_C177537 @default.
- NCIT_C95896 inSubset NCIT_C63923 @default.
- NCIT_C95896 type Class @default.
- NCIT_C95896 isDefinedBy ncit.owl @default.
- NCIT_C95896 label "Vorolanib" @default.
- NCIT_C95896 subClassOf NCIT_C129824 @default.
- NCIT_C95896 subClassOf NCIT_C129825 @default.
- NCIT_C95896 subClassOf NCIT_C1404 @default.
- NCIT_C95896 subClassOf NCIT_C163758 @default.
- NCIT_C95896 subClassOf NCIT_C163953 @default.
- NCIT_C95896 subClassOf NCIT_C1742 @default.
- NCIT_C95896 subClassOf NCIT_C1908 @default.
- NCIT_C95896 subClassOf NCIT_C1909 @default.
- NCIT_C95896 subClassOf NCIT_C1967 @default.
- NCIT_C95896 subClassOf NCIT_C2189 @default.
- NCIT_C95896 subClassOf NCIT_C274 @default.
- NCIT_C95896 subClassOf NCIT_C471 @default.
- NCIT_C95896 subClassOf NCIT_C93259 @default.
- NCIT_C95896 subClassOf NCIT_C95896 @default.