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- NCIT_C960 IAO_0000115 "A synthetic progestational agent similar to the endogenous progesterone used in hormone therapy or as a female contraceptive. Mimicking the action of progesterone, hydroxyprogesterone caporate binds to and activates nuclear progesterone receptors in the reproductive system and causes the ligand-receptor complex to be translocated to the nucleus where it binds to and promotes expression of target genes. Due to the negative feedback mechanism seen with progesterone, this agent also blocks luteinizing hormone (LH) release from the pituitary gland, thereby leading to an inhibition of ovulation and an alteration in the cervical mucus and endometrium. Furthermore, without stimulation of LH, estrogen release from the ovaries is stopped, hence impeding the growth of estrogen-sensitive tumor cells." @default.
- NCIT_C960 NCIT_A32 NCIT_C1909 @default.
- NCIT_C960 NCIT_NHC0 "C960" @default.
- NCIT_C960 NCIT_P106 "Organic Chemical" @default.
- NCIT_C960 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C960 NCIT_P108 "Hydroxyprogesterone Caproate" @default.
- NCIT_C960 NCIT_P175 "17592" @default.
- NCIT_C960 NCIT_P207 "C0044971" @default.
- NCIT_C960 NCIT_P210 "630-56-8" @default.
- NCIT_C960 NCIT_P302 "Endometrial cancer; amenorrhea" @default.
- NCIT_C960 NCIT_P319 "276F2O42F5" @default.
- NCIT_C960 NCIT_P322 "FDA" @default.
- NCIT_C960 NCIT_P322 "GDC" @default.
- NCIT_C960 NCIT_P329 "39803" @default.
- NCIT_C960 NCIT_P330 "39803" @default.
- NCIT_C960 NCIT_P350 "C27H40O4" @default.
- NCIT_C960 NCIT_P366 "Hydroxyprogesterone_Caproate" @default.
- NCIT_C960 NCIT_P375 "Hydroxyprogesterone Caproate" @default.
- NCIT_C960 NCIT_P399 "39803" @default.
- NCIT_C960 normalizedInformationContent "100" @default.
- NCIT_C960 referenceCount "1" @default.
- NCIT_C960 hasExactSynonym "17-[(1-Oxohexyl)oxy]pregn-4-ene-3,20-dione" @default.
- NCIT_C960 hasExactSynonym "17alpha-Hydroxyprogesterone Caproate" @default.
- NCIT_C960 hasExactSynonym "Delalutin" @default.
- NCIT_C960 hasExactSynonym "HYDROXYPROGESTERONE CAPROATE" @default.
- NCIT_C960 hasExactSynonym "Hydroxyprogesterone Caproate" @default.
- NCIT_C960 hasExactSynonym "Hydroxyprogesterone caproate" @default.
- NCIT_C960 hasExactSynonym "Makena" @default.
- NCIT_C960 inSubset NCIT_C128784 @default.
- NCIT_C960 inSubset NCIT_C157711 @default.
- NCIT_C960 inSubset NCIT_C157712 @default.
- NCIT_C960 inSubset NCIT_C176424 @default.
- NCIT_C960 inSubset NCIT_C177537 @default.
- NCIT_C960 inSubset NCIT_C63923 @default.
- NCIT_C960 type Class @default.
- NCIT_C960 isDefinedBy ncit.owl @default.
- NCIT_C960 label "Hydroxyprogesterone Caproate" @default.
- NCIT_C960 subClassOf NCIT_C147908 @default.
- NCIT_C960 subClassOf NCIT_C1636 @default.
- NCIT_C960 subClassOf NCIT_C1908 @default.
- NCIT_C960 subClassOf NCIT_C1909 @default.
- NCIT_C960 subClassOf NCIT_C548 @default.
- NCIT_C960 subClassOf NCIT_C776 @default.
- NCIT_C960 subClassOf NCIT_C960 @default.