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- NCIT_C96223 IAO_0000115 "A small molecule integrin receptor antagonist (IRA) with potential antineoplastic activity. Upon administration, GLPG0187 binds to and blocks the activity of 5 RGD-integrin receptor subtypes, including alphavbeta1, alphavbeta3, alphavbeta5, alphavbeta6 and alpha5beta1. This may result in the inhibition of endothelial cell-cell interactions and endothelial cell-matrix interactions, and the prevention of angiogenesis and metastasis in tumor cells expressing these integrin receptors. Integrin receptors are transmembrane glycoproteins expressed on the surface of tumor vessel endothelial cells and some types of cancer cells, and play a crucial role in endothelial cell adhesion and migration." @default.
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- NCIT_C96223 NCIT_NHC0 "C96223" @default.
- NCIT_C96223 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C96223 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C96223 NCIT_P108 "Integrin Receptor Antagonist GLPG0187" @default.
- NCIT_C96223 NCIT_P208 "CL429007" @default.
- NCIT_C96223 NCIT_P210 "1320346-97-1" @default.
- NCIT_C96223 NCIT_P319 "43A5P87Z4T" @default.
- NCIT_C96223 NCIT_P322 "FDA" @default.
- NCIT_C96223 NCIT_P322 "GDC" @default.
- NCIT_C96223 NCIT_P329 "697397" @default.
- NCIT_C96223 NCIT_P330 "697397" @default.
- NCIT_C96223 NCIT_P375 "Integrin Receptor Antagonist GLPG0187" @default.
- NCIT_C96223 NCIT_P399 "697397" @default.
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- NCIT_C96223 normalizedInformationContent "100" @default.
- NCIT_C96223 referenceCount "1" @default.
- NCIT_C96223 hasExactSynonym "GLPG-0187" @default.
- NCIT_C96223 hasExactSynonym "GLPG0187" @default.
- NCIT_C96223 hasExactSynonym "Integrin Receptor Antagonist GLPG0187" @default.
- NCIT_C96223 inSubset NCIT_C128784 @default.
- NCIT_C96223 inSubset NCIT_C157711 @default.
- NCIT_C96223 inSubset NCIT_C157712 @default.
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- NCIT_C96223 inSubset NCIT_C63923 @default.
- NCIT_C96223 type Class @default.
- NCIT_C96223 isDefinedBy ncit.owl @default.
- NCIT_C96223 label "Integrin Receptor Antagonist GLPG0187" @default.
- NCIT_C96223 subClassOf B3ca8ee0436110fd77bde1f406a7da565 @default.
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- NCIT_C96223 subClassOf NCIT_C1742 @default.
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- NCIT_C96223 subClassOf NCIT_C96223 @default.