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- NCIT_C96227 IAO_0000115 "A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; cFMS) with potential antineoplastic activity. cFMS tyrosine kinase inhibitor ARRY-382 binds to and inhibits the activity of cFMS. By preventing colony-stimulating factor-1 (CSF-1)-cFMS signaling, this agent may inhibit tumor cell proliferation in cFMS-overexpressing tumor cells. cFMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation and regulation of cell proliferation." @default.
- NCIT_C96227 NCIT_A32 NCIT_C1909 @default.
- NCIT_C96227 NCIT_A7 NCIT_C17392 @default.
- NCIT_C96227 NCIT_NHC0 "C96227" @default.
- NCIT_C96227 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C96227 NCIT_P107 "cFMS Tyrosine Kinase Inhibitor ARRY-382" @default.
- NCIT_C96227 NCIT_P108 "cFMS Tyrosine Kinase Inhibitor ARRY-382" @default.
- NCIT_C96227 NCIT_P208 "CL429011" @default.
- NCIT_C96227 NCIT_P322 "CTRP" @default.
- NCIT_C96227 NCIT_P322 "GDC" @default.
- NCIT_C96227 NCIT_P329 "697525" @default.
- NCIT_C96227 NCIT_P330 "697525" @default.
- NCIT_C96227 NCIT_P375 "cFMS Tyrosine Kinase Inhibitor ARRY-382" @default.
- NCIT_C96227 NCIT_P399 "697525" @default.
- NCIT_C96227 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C96227 NCIT_R125 NCIT_C17828 @default.
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- NCIT_C96227 normalizedInformationContent "100" @default.
- NCIT_C96227 referenceCount "1" @default.
- NCIT_C96227 hasExactSynonym "ARRY-382" @default.
- NCIT_C96227 hasExactSynonym "cFMS Tyrosine Kinase Inhibitor ARRY-382" @default.
- NCIT_C96227 inSubset NCIT_C116977 @default.
- NCIT_C96227 inSubset NCIT_C116978 @default.
- NCIT_C96227 inSubset NCIT_C128784 @default.
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- NCIT_C96227 inSubset NCIT_C176424 @default.
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- NCIT_C96227 type Class @default.
- NCIT_C96227 isDefinedBy ncit.owl @default.
- NCIT_C96227 label "cFMS Tyrosine Kinase Inhibitor ARRY-382" @default.
- NCIT_C96227 subClassOf B1ad11b45a71643112cadb57d916fde43 @default.
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- NCIT_C96227 subClassOf NCIT_C1967 @default.
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- NCIT_C96227 subClassOf NCIT_C274 @default.
- NCIT_C96227 subClassOf NCIT_C471 @default.
- NCIT_C96227 subClassOf NCIT_C96227 @default.