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- NCIT_C96229 IAO_0000115 "A replication-competent oncolytic parvovirus with potential antineoplastic activity. Upon infection of host cells, parvovirus H-1 preferentially replicates in tumor cells compared to healthy normal cells, thereby potentially resulting in tumor cell lysis and leading to an inhibition of tumor cell proliferation. In addition, H1-infected tumor cells strongly induce the release of the inducible heat shock protein 72 (Hsp72i), which chaperone tumor associated antigens in the H1-mediated tumor lysates and may activate antigen presenting cells (APCs), thereby leading to antitumor immune responses. Parvovirus H-1 does not cause any pathogenic effect in normal, healthy cells and is able to cross the blood brain barrier (BBB)." @default.
- NCIT_C96229 NCIT_A32 NCIT_C1909 @default.
- NCIT_C96229 NCIT_NHC0 "C96229" @default.
- NCIT_C96229 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C96229 NCIT_P106 "Virus" @default.
- NCIT_C96229 NCIT_P108 "Parvovirus H-1" @default.
- NCIT_C96229 NCIT_P207 "C0319116" @default.
- NCIT_C96229 NCIT_P322 "GDC" @default.
- NCIT_C96229 NCIT_P329 "697624" @default.
- NCIT_C96229 NCIT_P330 "697624" @default.
- NCIT_C96229 NCIT_P375 "Parvovirus H-1" @default.
- NCIT_C96229 NCIT_P399 "697624" @default.
- NCIT_C96229 normalizedInformationContent "100" @default.
- NCIT_C96229 referenceCount "1" @default.
- NCIT_C96229 hasExactSynonym "H-1PV" @default.
- NCIT_C96229 hasExactSynonym "ParvOryx" @default.
- NCIT_C96229 hasExactSynonym "Parvovirus H-1" @default.
- NCIT_C96229 inSubset NCIT_C128784 @default.
- NCIT_C96229 inSubset NCIT_C157711 @default.
- NCIT_C96229 inSubset NCIT_C157712 @default.
- NCIT_C96229 inSubset NCIT_C176424 @default.
- NCIT_C96229 inSubset NCIT_C177537 @default.
- NCIT_C96229 type Class @default.
- NCIT_C96229 isDefinedBy ncit.owl @default.
- NCIT_C96229 label "Parvovirus H-1" @default.
- NCIT_C96229 subClassOf NCIT_C129821 @default.
- NCIT_C96229 subClassOf NCIT_C1908 @default.
- NCIT_C96229 subClassOf NCIT_C1909 @default.
- NCIT_C96229 subClassOf NCIT_C274 @default.
- NCIT_C96229 subClassOf NCIT_C307 @default.
- NCIT_C96229 subClassOf NCIT_C717 @default.
- NCIT_C96229 subClassOf NCIT_C96229 @default.