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- NCIT_C96293 IAO_0000115 "The mesylate salt form of nafamostat, a broad-spectrum, synthetic serine protease inhibitor, with anticoagulant, anti-inflammatory, mucus clearing, and potential antiviral activities. Upon administration, nafamostat inhibits the activities of a variety of proteases, including thrombin, plasmin, kallikrein, trypsin, and Cl esterase in the complement system, and factors VIIa, Xa, and XIIa in the coagulation system. Although the mechanism of action of nafamostat is not fully understood, trypsinogen activation in the pancreas is known to be a trigger reaction in the development of pancreatitis. Nafamostat blocks the activation of trypsinogen to trypsin and the inflammatory cascade that follows. Nafamostat may also decrease epithelial sodium channel (ENaC) activity and increase mucus clearance in the airways. ENaC activity is increased in cystic fibrosis. In addition, nafamostat may inhibit the activity of transmembrane protease, serine 2 (TMPRSS2), a host cell serine protease that mediates viral cell entry for influenza virus and coronavirus, thereby inhibiting viral infection and replication." @default.
- NCIT_C96293 NCIT_A6 NCIT_C96292 @default.
- NCIT_C96293 NCIT_NHC0 "C96293" @default.
- NCIT_C96293 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C96293 NCIT_P108 "Nafamostat Mesylate" @default.
- NCIT_C96293 NCIT_P171 "21187179" @default.
- NCIT_C96293 NCIT_P207 "C0207682" @default.
- NCIT_C96293 NCIT_P210 "82956-11-4" @default.
- NCIT_C96293 NCIT_P319 "1D2T74921W" @default.
- NCIT_C96293 NCIT_P322 "FDA" @default.
- NCIT_C96293 NCIT_P350 "C19H17N5O2.2CH4O3S" @default.
- NCIT_C96293 normalizedInformationContent "100" @default.
- NCIT_C96293 referenceCount "1" @default.
- NCIT_C96293 hasExactSynonym "6-Amidino-2-naphthyl 4-guanidinobenzoate Dimethanesulfonate" @default.
- NCIT_C96293 hasExactSynonym "Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester, Dimethanesulfonate" @default.
- NCIT_C96293 hasExactSynonym "CKD-314" @default.
- NCIT_C96293 hasExactSynonym "FUT 175" @default.
- NCIT_C96293 hasExactSynonym "FUT-175" @default.
- NCIT_C96293 hasExactSynonym "FUT175" @default.
- NCIT_C96293 hasExactSynonym "NAFAMOSTAT MESYLATE" @default.
- NCIT_C96293 hasExactSynonym "Nafamostat Dimethanesulfonate" @default.
- NCIT_C96293 hasExactSynonym "Nafamostat Mesilate" @default.
- NCIT_C96293 hasExactSynonym "Nafamostat Mesylate" @default.
- NCIT_C96293 inSubset NCIT_C173381 @default.
- NCIT_C96293 inSubset NCIT_C173383 @default.
- NCIT_C96293 inSubset NCIT_C63923 @default.
- NCIT_C96293 type Class @default.
- NCIT_C96293 isDefinedBy ncit.owl @default.
- NCIT_C96293 label "Nafamostat Mesylate" @default.
- NCIT_C96293 subClassOf NCIT_C1908 @default.
- NCIT_C96293 subClassOf NCIT_C1909 @default.
- NCIT_C96293 subClassOf NCIT_C2198 @default.
- NCIT_C96293 subClassOf NCIT_C2356 @default.
- NCIT_C96293 subClassOf NCIT_C241 @default.
- NCIT_C96293 subClassOf NCIT_C257 @default.
- NCIT_C96293 subClassOf NCIT_C471 @default.
- NCIT_C96293 subClassOf NCIT_C78272 @default.
- NCIT_C96293 subClassOf NCIT_C783 @default.
- NCIT_C96293 subClassOf NCIT_C96293 @default.