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- NCIT_C96366 IAO_0000115 "A recombinant form of human complement component 1 esterase inhibitor (C1INH), a serine protease inhibitor normally present in human plasma, that can be used for the treatment of hereditary angioedema (HAE). Upon administration, conestat alfa irreversibly binds to and inhibits the activities of several proteases of the contact and complement systems, which may include activated C1s, kallikrein, factor XIIa and factor XIa, blocking the activation of the contact and complement systems. This may prevent inflammation and the production of bradykinin (BK), thereby blocking BK-driven increase in vascular permeability and the resulting edema." @default.
- NCIT_C96366 NCIT_A9 NCIT_C87730 @default.
- NCIT_C96366 NCIT_NHC0 "C96366" @default.
- NCIT_C96366 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C96366 NCIT_P108 "Conestat Alfa" @default.
- NCIT_C96366 NCIT_P207 "C3195420" @default.
- NCIT_C96366 NCIT_P210 "80295-38-1" @default.
- NCIT_C96366 NCIT_P319 "5QS67N4551" @default.
- NCIT_C96366 NCIT_P322 "FDA" @default.
- NCIT_C96366 normalizedInformationContent "100" @default.
- NCIT_C96366 referenceCount "1" @default.
- NCIT_C96366 hasExactSynonym "C1 Esterase Inhibitor Protein" @default.
- NCIT_C96366 hasExactSynonym "C1-INH Protein" @default.
- NCIT_C96366 hasExactSynonym "C1INH Protein" @default.
- NCIT_C96366 hasExactSynonym "CONESTAT ALFA" @default.
- NCIT_C96366 hasExactSynonym "Complement C1 Inhibitor Protein" @default.
- NCIT_C96366 hasExactSynonym "Conestat Alfa" @default.
- NCIT_C96366 hasExactSynonym "Ruconest" @default.
- NCIT_C96366 inSubset NCIT_C173381 @default.
- NCIT_C96366 inSubset NCIT_C173383 @default.
- NCIT_C96366 inSubset NCIT_C63923 @default.
- NCIT_C96366 type Class @default.
- NCIT_C96366 isDefinedBy ncit.owl @default.
- NCIT_C96366 label "Conestat Alfa" @default.
- NCIT_C96366 subClassOf NCIT_C1908 @default.
- NCIT_C96366 subClassOf NCIT_C1909 @default.
- NCIT_C96366 subClassOf NCIT_C199456 @default.
- NCIT_C96366 subClassOf NCIT_C29726 @default.
- NCIT_C96366 subClassOf NCIT_C307 @default.
- NCIT_C96366 subClassOf NCIT_C308 @default.
- NCIT_C96366 subClassOf NCIT_C471 @default.
- NCIT_C96366 subClassOf NCIT_C78275 @default.
- NCIT_C96366 subClassOf NCIT_C783 @default.
- NCIT_C96366 subClassOf NCIT_C96366 @default.