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- NCIT_C96532 IAO_0000115 "An orally bioavailable inhibitor of the alpha and beta isoforms of p38 mitogen-activated protein kinase (MAPK), with potential immunomodulating and anti-inflammatory activities. Upon oral administration, losmapimod inhibits the activity of p38alpha/beta MAPK, thereby preventing p38alpha/beta MAPK-mediated signaling. This may result in the inhibition of the production of proinflammatory cytokines. p38 MAPK, a serine/threonine protein kinase, plays an important role in regulating the transcription and translation of cytokines involved in inflammation including tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1, IL-6 and IL-8." @default.
- NCIT_C96532 NCIT_NHC0 "C96532" @default.
- NCIT_C96532 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C96532 NCIT_P108 "Losmapimod" @default.
- NCIT_C96532 NCIT_P207 "C3272847" @default.
- NCIT_C96532 NCIT_P210 "585543-15-3" @default.
- NCIT_C96532 NCIT_P319 "F2DQF16BXE" @default.
- NCIT_C96532 NCIT_P322 "FDA" @default.
- NCIT_C96532 NCIT_P350 "C22H26FN3O2" @default.
- NCIT_C96532 normalizedInformationContent "100" @default.
- NCIT_C96532 referenceCount "1" @default.
- NCIT_C96532 hasExactSynonym "3-pyridinecarboxamide, 6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-n-(2,2-dimethylpropyl)-" @default.
- NCIT_C96532 hasExactSynonym "6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-n-(2,2-dimethylpropyl)-3-pyridinecarboxamide" @default.
- NCIT_C96532 hasExactSynonym "GW-856553X" @default.
- NCIT_C96532 hasExactSynonym "GW856553X" @default.
- NCIT_C96532 hasExactSynonym "LOSMAPIMOD" @default.
- NCIT_C96532 hasExactSynonym "Losmapimod" @default.
- NCIT_C96532 inSubset NCIT_C173381 @default.
- NCIT_C96532 inSubset NCIT_C173383 @default.
- NCIT_C96532 inSubset NCIT_C63923 @default.
- NCIT_C96532 type Class @default.
- NCIT_C96532 isDefinedBy ncit.owl @default.
- NCIT_C96532 label "Losmapimod" @default.
- NCIT_C96532 subClassOf NCIT_C1404 @default.
- NCIT_C96532 subClassOf NCIT_C163758 @default.
- NCIT_C96532 subClassOf NCIT_C1908 @default.
- NCIT_C96532 subClassOf NCIT_C1909 @default.
- NCIT_C96532 subClassOf NCIT_C2149 @default.
- NCIT_C96532 subClassOf NCIT_C274 @default.
- NCIT_C96532 subClassOf NCIT_C471 @default.
- NCIT_C96532 subClassOf NCIT_C61074 @default.
- NCIT_C96532 subClassOf NCIT_C96532 @default.