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- NCIT_C96735 IAO_0000115 "A recombinant vaccine containing a genetically detoxified adenylate cyclase toxin (CyaA) of Bordetella pertussis coupled, through its catalytic site, to the melanoma tyrosinase A2 epitope YMDGTMSQV, with potential antineoplastic activity. Via the toxin moiety, the recombinant B. pertussis adenylate cyclase toxin-tyrosinase A2 epitope specifically binds to the alphaMbeta2 integrin (CD11b/CD18) located on CD11b-positive antigen-presenting cells (APC). Upon processing and presentation of the melanoma-specific epitope by MHC class I molecules to the surface of these APCs, a specific cytotoxic T-cell (CTL) response against tumor cells expressing tyrosinase may be initiated, resulting in decreased tumor growth and cell lysis." @default.
- NCIT_C96735 NCIT_NHC0 "C96735" @default.
- NCIT_C96735 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C96735 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C96735 NCIT_P108 "Recombinant B. pertussis Adenylate Cyclase Toxin-Tyrosinase A2 Epitope Vaccine" @default.
- NCIT_C96735 NCIT_P208 "CL429360" @default.
- NCIT_C96735 NCIT_P329 "698993" @default.
- NCIT_C96735 NCIT_P330 "698993" @default.
- NCIT_C96735 NCIT_P399 "698993" @default.
- NCIT_C96735 normalizedInformationContent "100" @default.
- NCIT_C96735 referenceCount "1" @default.
- NCIT_C96735 hasExactSynonym "Recombinant B. pertussis Adenylate Cyclase Toxin-Tyrosinase A2 Epitope Vaccine" @default.
- NCIT_C96735 hasExactSynonym "Recombinant Bordetella pertussis Adenylate Cyclase Toxin-Tyrosinase.A2 Epitope YMDGTMSQV Vaccine" @default.
- NCIT_C96735 inSubset NCIT_C128784 @default.
- NCIT_C96735 inSubset NCIT_C176424 @default.
- NCIT_C96735 type Class @default.
- NCIT_C96735 isDefinedBy ncit.owl @default.
- NCIT_C96735 label "Recombinant B. pertussis Adenylate Cyclase Toxin-Tyrosinase A2 Epitope Vaccine" @default.
- NCIT_C96735 subClassOf NCIT_C129820 @default.
- NCIT_C96735 subClassOf NCIT_C1663 @default.
- NCIT_C96735 subClassOf NCIT_C1908 @default.
- NCIT_C96735 subClassOf NCIT_C1909 @default.
- NCIT_C96735 subClassOf NCIT_C2517 @default.
- NCIT_C96735 subClassOf NCIT_C274 @default.
- NCIT_C96735 subClassOf NCIT_C307 @default.
- NCIT_C96735 subClassOf NCIT_C308 @default.
- NCIT_C96735 subClassOf NCIT_C923 @default.
- NCIT_C96735 subClassOf NCIT_C96735 @default.