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- NCIT_C96737 IAO_0000115 "A fusion DNA vaccine containing the first domain of fragment C (FrC) of tetanus toxin (TT865-1120) (p.DOM) fused to the human Wilms' Tumor gene-1 (WT1)-derived MHC class I-binding epitope WT1.37, with potential antitumor activity. Upon vaccination with p.DOM-WT1-37 DNA and subsequent electroporation, this vaccine may induce a WT1 epitope-specific cytotoxic T-lymphocyte (CTL) response against WT1 expressing cells, resulting in cell lysis and inhibition of cancer cell proliferation in WT1-overexpressing cancer cells. WT1, a tumor associated antigen, is overexpressed in most types of leukemia and in a variety of solid cancers. The FrC of tetanus toxin contains the MHC II-binding sequence, p30, which induces T-helper cell activation for long-lasting immunity." @default.
- NCIT_C96737 NCIT_NHC0 "C96737" @default.
- NCIT_C96737 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C96737 NCIT_P108 "p.DOM-WT1-37 DNA Vaccine" @default.
- NCIT_C96737 NCIT_P208 "CL429362" @default.
- NCIT_C96737 NCIT_P329 "699215" @default.
- NCIT_C96737 NCIT_P330 "699215" @default.
- NCIT_C96737 NCIT_P399 "699215" @default.
- NCIT_C96737 normalizedInformationContent "100" @default.
- NCIT_C96737 referenceCount "1" @default.
- NCIT_C96737 hasExactSynonym "p.DOM-WT1-37 DNA Vaccine" @default.
- NCIT_C96737 inSubset NCIT_C128784 @default.
- NCIT_C96737 inSubset NCIT_C176424 @default.
- NCIT_C96737 type Class @default.
- NCIT_C96737 isDefinedBy ncit.owl @default.
- NCIT_C96737 label "p.DOM-WT1-37 DNA Vaccine" @default.
- NCIT_C96737 subClassOf NCIT_C129820 @default.
- NCIT_C96737 subClassOf NCIT_C1663 @default.
- NCIT_C96737 subClassOf NCIT_C1908 @default.
- NCIT_C96737 subClassOf NCIT_C1909 @default.
- NCIT_C96737 subClassOf NCIT_C274 @default.
- NCIT_C96737 subClassOf NCIT_C307 @default.
- NCIT_C96737 subClassOf NCIT_C308 @default.
- NCIT_C96737 subClassOf NCIT_C39619 @default.
- NCIT_C96737 subClassOf NCIT_C923 @default.
- NCIT_C96737 subClassOf NCIT_C96737 @default.