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- NCIT_C96739 IAO_0000115 "A cancer vaccine containing autologous dendritic cells (DCs) that are transfected with mRNAs extracted from amplified ovarian cancer stem cells, and mRNAs of the universal tumor antigens human telomerase reverse transcriptase (hTERT) and survivin with potential immunostimulatory and antineoplastic activities. Upon administration, ovarian cancer stem cell/hTERT/survivin mRNAs-loaded autologous DC-006 vaccine may elicit a highly specific cytotoxic T-cell (CTL) response against ovarian cancer cells expressing hTERT, survivin, and specific ovarian cancer stem cell antigens. hTERT, the catalytic subunit of human telomerase, and survivin, a member of the inhibitor of apoptosis (IAP) family of proteins, may be upregulated in certain tumor cell types, playing key roles in tumor cell growth and survival. Ovarian cancer stem cells contain a specific range of antigens that are essential for the neoplastic growth and survival of ovarian cancer cells." @default.
- NCIT_C96739 NCIT_A32 NCIT_C1909 @default.
- NCIT_C96739 NCIT_NHC0 "C96739" @default.
- NCIT_C96739 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C96739 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C96739 NCIT_P108 "Ovarian Cancer Stem Cell/hTERT/Survivin mRNAs-loaded Autologous Dendritic Cell Vaccine DC-006" @default.
- NCIT_C96739 NCIT_P208 "CL429364" @default.
- NCIT_C96739 NCIT_P322 "GDC" @default.
- NCIT_C96739 NCIT_P329 "699229" @default.
- NCIT_C96739 NCIT_P330 "699229" @default.
- NCIT_C96739 NCIT_P375 "Ovarian Cancer Stem Cell/hTERT/Survivin mRNAs-loaded Autologous Dendritic Cell Vaccine DC-006" @default.
- NCIT_C96739 NCIT_P399 "699229" @default.
- NCIT_C96739 normalizedInformationContent "100" @default.
- NCIT_C96739 referenceCount "1" @default.
- NCIT_C96739 hasExactSynonym "DC-006 Vaccine" @default.
- NCIT_C96739 hasExactSynonym "DC-006" @default.
- NCIT_C96739 hasExactSynonym "Ovarian Cancer Stem Cell/hTERT/Survivin mRNAs-loaded Autologous Dendritic Cell Vaccine DC-006" @default.
- NCIT_C96739 inSubset NCIT_C128784 @default.
- NCIT_C96739 inSubset NCIT_C157711 @default.
- NCIT_C96739 inSubset NCIT_C157712 @default.
- NCIT_C96739 inSubset NCIT_C176424 @default.
- NCIT_C96739 inSubset NCIT_C177537 @default.
- NCIT_C96739 type Class @default.
- NCIT_C96739 isDefinedBy ncit.owl @default.
- NCIT_C96739 label "Ovarian Cancer Stem Cell/hTERT/Survivin mRNAs-loaded Autologous Dendritic Cell Vaccine DC-006" @default.
- NCIT_C96739 subClassOf NCIT_C129820 @default.
- NCIT_C96739 subClassOf NCIT_C1663 @default.
- NCIT_C96739 subClassOf NCIT_C172787 @default.
- NCIT_C96739 subClassOf NCIT_C181141 @default.
- NCIT_C96739 subClassOf NCIT_C1908 @default.
- NCIT_C96739 subClassOf NCIT_C1909 @default.
- NCIT_C96739 subClassOf NCIT_C274 @default.
- NCIT_C96739 subClassOf NCIT_C28308 @default.
- NCIT_C96739 subClassOf NCIT_C28310 @default.
- NCIT_C96739 subClassOf NCIT_C307 @default.
- NCIT_C96739 subClassOf NCIT_C308 @default.
- NCIT_C96739 subClassOf NCIT_C923 @default.
- NCIT_C96739 subClassOf NCIT_C96739 @default.