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- NCIT_C96742 IAO_0000115 "A locked nucleic acid (LNA)-based antisense oligonucleotide targeting the androgen receptor (AR) mRNA, with potential antineoplastic activity. Upon administration, EZN-4176 is hybridized and releases the complementary sequences of AR mRNA, thereby blocking translation of the AR protein and inhibiting AR-induced tumor cell growth and promoting tumor cell apoptosis in AR-overexpressing tumor cells. AR is overexpressed in certain breast and prostate cancers and is involved in tumor cell proliferation and survival. LNAs contain a methylene bridge linking 2'-oxygen and 4'-carbon of ribose sugar rings, thereby increasing their thermal stability and decreasing degradation." @default.
- NCIT_C96742 NCIT_A32 NCIT_C1909 @default.
- NCIT_C96742 NCIT_NHC0 "C96742" @default.
- NCIT_C96742 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C96742 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C96742 NCIT_P108 "Androgen Receptor Antisense Oligonucleotide EZN-4176" @default.
- NCIT_C96742 NCIT_P207 "C3273001" @default.
- NCIT_C96742 NCIT_P322 "GDC" @default.
- NCIT_C96742 NCIT_P329 "699628" @default.
- NCIT_C96742 NCIT_P330 "699628" @default.
- NCIT_C96742 NCIT_P375 "Androgen Receptor Antisense Oligonucleotide EZN-4176" @default.
- NCIT_C96742 NCIT_P399 "699628" @default.
- NCIT_C96742 normalizedInformationContent "100" @default.
- NCIT_C96742 referenceCount "1" @default.
- NCIT_C96742 hasExactSynonym "Androgen Receptor Antisense Oligonucleotide EZN-4176" @default.
- NCIT_C96742 hasExactSynonym "EZN-4176" @default.
- NCIT_C96742 inSubset NCIT_C128784 @default.
- NCIT_C96742 inSubset NCIT_C157711 @default.
- NCIT_C96742 inSubset NCIT_C157712 @default.
- NCIT_C96742 inSubset NCIT_C176424 @default.
- NCIT_C96742 inSubset NCIT_C177537 @default.
- NCIT_C96742 type Class @default.
- NCIT_C96742 isDefinedBy ncit.owl @default.
- NCIT_C96742 label "Androgen Receptor Antisense Oligonucleotide EZN-4176" @default.
- NCIT_C96742 subClassOf NCIT_C1291 @default.
- NCIT_C96742 subClassOf NCIT_C1908 @default.
- NCIT_C96742 subClassOf NCIT_C1909 @default.
- NCIT_C96742 subClassOf NCIT_C1962 @default.
- NCIT_C96742 subClassOf NCIT_C307 @default.
- NCIT_C96742 subClassOf NCIT_C96742 @default.